Development of novel approaches for regulating the expression of angiotensin-converting
enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) is becoming …

There is a great need for novel in vitro methods to predict human developmental toxicity to
comply with the 3R principles and to improve human safety. Human-induced pluripotent …

For some complex toxicological endpoints, chemical safety assessment has conventionally
relied on animal testing. Apart from the ethical issues, also scientific considerations have …

The first in vitro tests for developmental toxicity made use of rodent cells. Newer teratology
tests, eg developed during the ESNATS project, use human cells and measure mechanistic …

Many toxicological test methods, including assays of cell viability and function, require an
evaluation of concentration-response data. This often involves curve fitting, and the resulting …

Thousands of transcriptome data sets are available, but approaches for their use in dynamic
cell response modelling are few, especially for processes affected simultaneously by two …

Human induced pluripotent stem cells (hiPSC) were used to develop an assay format that
may deliver information on teratogenicity of drugs. A human pluripotent stem cell scorecard …

There is a need for in vitro tests for the evaluation of chemicals and pharmaceuticals that
may cause developmental neurotoxicity (DNT) in humans. The neural embryonic stem cell …

Currently, many research activities in the field of in vitro models focus at predicting human
organ toxicity, eg of the liver (Gomez-Lechon et al., 2014; Grinberg et al., 2014, 2018; Frey et …

Recently, Santamaria and colleagues published a dermal exposure study with
benzophenone-3 in pregnant mice to study the possible effects on the outcome of the …