PGC-1α-mediated regulation of mitochondrial function and physiological implications

JF Halling, H Pilegaard - Applied Physiology, Nutrition, and …, 2020 - cdnsciencepub.com
The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …

[HTML][HTML] Anti-diabetic effect by walnut (Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting α-glucosidase and α-amylase, and alleviating insulin …

J Wang, T Wu, L Fang, C Liu, X Liu, H Li, J Shi… - Journal of Functional …, 2020 - Elsevier
In the present study, a novel pentapeptide LPLLR (Leu-Pro-Leu-Leu-Arg) was purified and
identified from walnut protein hydrolysates (3–10 kDa) by SEC, RP-HPLC, and LC-MS/MS …

Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice

H Wang, S Kuusela, R Rinnankoski-Tuikka… - International Journal of …, 2020 - nature.com
Objective Human TNKS, encoding tankyrase 1 (TNKS1), localizes to a susceptibility locus
for obesity and type 2 diabetes mellitus (T2DM). Here, we addressed the therapeutic …