Emergence and significance of carbohydrate-specific antibodies

K Kappler, T Hennet - Genes & Immunity, 2020 - nature.com
Carbohydrate-specific antibodies are widespread among all classes of immunoglobulins.
Despite their broad occurrence, little is known about their formation and biological …

DNA-based microarray studies in visceral leishmaniasis: identification of biomarkers for diagnostic, prognostic and drug target for treatment

A Kumar, SC Pandey, M Samant - Acta tropica, 2020 - Elsevier
Visceral leishmaniasis (VL) is one of the major infectious diseases affecting the poorest
regions of the world. Current therapy is not very much satisfactory. The alarming rise of drug …

Synthetic carbohydrate chemistry and translational medicine

SS Shivatare, CH Wong - The Journal of organic chemistry, 2020 - ACS Publications
The importance of post-translational glycosylation in protein structure and function has
gained significant clinical relevance recently. The latest developments in glycobiology …

Antibodies, binding fragments, and methods of use

NH Lin, CC Huang, CY Chen, CHU Kuo-Ching… - US Patent …, 2020 - Google Patents
2017-09-11 Assigned to OBI PHARMA INC. reassignment OBI PHARMA INC. ASSIGNMENT
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LIN, NAN …

Synthesis, Molecular Docking, and Preliminary Evaluation of 2‐(1, 2, 3‐Triazoyl) benzaldehydes As Multifunctional Agents for the Treatment of Alzheimer's Disease

GP Costa, RSM Baldinotti, MG Fronza… - …, 2020 - Wiley Online Library
We described here our results on the use of thiourea as a ligand in the copper catalysed
azide‐alkyne cycloaddition (CuAAC) of 2‐azidobenzaldehyde with alkynes. Reactions were …

Preparation and uses of chlorinated glycerol derivatives

A Canela-Xandri, M Balcells, G Villorbina, P Christou… - Molecules, 2020 - mdpi.com
Crude glycerol (C3H8O3) is a major by-product of biodiesel production from vegetable oils
and animal fats. The increased biodiesel production in the last two decades has forced …

Hydrogen-bond-mediated aglycone delivery (HAD) and related methods in carbohydrate chemistry

MP Mannino, AV Demchenko - 2020 - books.rsc.org
The stereocontrol of glycosylation reactions is a constant struggle in the field of synthetic
carbohydrate chemistry. The application of the picoloyl (Pico) substituent can offer numerous …

Anti-HER2 glycoantibodies and uses thereof

CH Wong, CY Wu - US Patent 10,618,973, 2020 - Google Patents
4,137.230 A 1/1979 Hashimoto et al. the ikMkk antibodies that have not 4,151,042 A 4/1979
Higashide et al. een glycoengıneered. 4.248. 870 A 2/1981 Miyashita et al. 4,256,746 A …

Label-Free Biosensors for Studying Carbohydrate-Protein Interaction

A Rehman, L Li, X Zeng - Glycan-Based Cellular Communication …, 2020 - ACS Publications
Carbohydrate-protein interactions are omnipresent in nature controlling critical functions of
cell proliferation, cell adhesion, and cell migration in the human body. However, the detailed …

Functionalized CARB Pharmacophore (FCP) approach to thio and unsaturated carbohydrate scaffolds with potential anticancer activity

ZJ Witczak, R Bielski, T Poplawski - 2020 - books.rsc.org
This brief review discusses some new developments in the functionalized carb
pharmacophore (FCP) concept introduced by us in 2014. While the examples concentrate …