Apoptosis in the cystic epithelium is observed in most rodent models of polycystic kidney
disease (PKD) and in human autosomal dominant PKD (ADPKD). Apoptosis inhibition …

Metformin is a frontline hypoglycemic agent, which is mainly prescribed to manage type 2
diabetes mellitus with obesity. Emerging evidence suggests that metformin also exerts …

While constant basal levels of macroautophagy/autophagy are a prerequisite to preserve
long-lived podocytes at the filtration barrier, MTOR regulates at the same time podocyte size …

Autophagy is a cell self-renewal process that relies on the degradation of the cytoplasmic
proteins or organelles of lysosomes and is associated with development of numerous …

Kidney fibrosis is characterized by expansion and activation of platelet‐derived growth factor
receptor‐β (PDGFR‐β)‐positive mesenchymal cells. To study the consequences of PDGFR …

Klotho-and beclin 1-driven autophagy extends life. We examined the role of beclin 1 in
modifying acute kidney injury (AKI) and whether beclin 1 mediates Klotho's known …

Renal fibrosis is the most common pathological manifestation of chronic kidney disease
(CKD), and with numerous influencing factors, its pathogenesis is complex. Epithelial …

Heat stress can particularly affect the kidney because of its high rate of adenosine
triphosphate consumption. Competition between apoptosis and autophagy-mediated …

Diabetic kidney disease (DKD) is the most common cause of severe renal disease
worldwide and the single strongest predictor of mortality in diabetes patients. Kidney …

Recent data from the World Population Prospects projects that, by 2050, nearly all regions in
the world will have a quarter or more of the population aged 60 and above. Chronic kidney …