As the prevalence of obesity continues to grow worldwide, the health and financial burden of
obesity-related comorbidities grows too. Cardiovascular disease (CVD) is clearly associated …

Cardiovascular diseases (CVD) are the leading cause of death worldwide and aging is the
primary risk factor for CVD. The development of vascular dysfunction, including endothelial …

Background: Development of albuminuria and arterial stiffness in Munich Wistar Frömter
(MWF) rats, a model of chronic kidney disease, is related to alterations in extracellular …

Insulin resistance in the vasculature is a characteristic feature of obesity and contributes to
the pathogenesis of vascular dysfunction and disease. However, the molecular mechanisms …

A Western-style diet (WD; high in fat and carbohydrates) increases vascular oxidative stress.
We hypothesized that vascular cells adapt to a WD by developing resilience to oxidative …

Rationale: The PTH1R (PTH [parathyroid hormone]/PTHrP [PTH-related protein] receptor) is
expressed in vascular smooth muscle (VSM) and increased VSM PTH1R signaling mitigates …

Type 2 diabetic (T2DM) coronary resistance microvessels (CRMs) undergo inward
hypertrophic remodeling associated with reduced stiffness and reduced coronary blood flow …

High-fructose intake induces hypertension via the renal expression of (pro) renin receptor
(PRR) that stimulates the expression of sodium/hydrogen exchanger 3, Na/K/2Cl …

Consumption of a Western diet (WD) induces central aortic stiffening that contributes to the
transmittance of pulsatile blood flow to end organs, including the kidney. Our recent work …

Hypertension is a worldwide known cause of morbidity and mortality in the elderly and is a
major risk factor for cardiovascular complications such as stroke, myocardial infarction, renal …