[HTML][HTML] RNA-binding proteins in tumor progression
H Qin, H Ni, Y Liu, Y Yuan, T Xi, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …
important biological functions. They are critical to maintain the transcriptome through post …
[HTML][HTML] Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer
Y Chen, Y Lin, Y Shu, J He, W Gao - Molecular cancer, 2020 - Springer
As a critical internal RNA modification in higher eukaryotes, N 6-methyladenosine (m 6 A)
has become the hotspot of epigenetics research in recent years. Extensive studies on …
has become the hotspot of epigenetics research in recent years. Extensive studies on …
RIC-seq for global in situ profiling of RNA–RNA spatial interactions
Z Cai, C Cao, L Ji, R Ye, D Wang, C Xia, S Wang, Z Du… - Nature, 2020 - nature.com
Highly structured RNA molecules usually interact with each other, and associate with
various RNA-binding proteins, to regulate critical biological processes. However, RNA …
various RNA-binding proteins, to regulate critical biological processes. However, RNA …
[HTML][HTML] RNA-GPS predicts SARS-CoV-2 RNA residency to host mitochondria and nucleolus
SARS-CoV-2 genomic and subgenomic RNA (sgRNA) transcripts hijack the host cell's
machinery. Subcellular localization of its viral RNA could, thus, play important roles in viral …
machinery. Subcellular localization of its viral RNA could, thus, play important roles in viral …
Inhibition of RNA-binding proteins with small molecules
P Wu - Nature Reviews Chemistry, 2020 - nature.com
Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …
dysregulated, can lead to a range of human diseases. The identification of small molecules …
[HTML][HTML] An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
Abstract Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic
individuals, and its expression and signaling are regulated by T1D genetic risk variants and …
individuals, and its expression and signaling are regulated by T1D genetic risk variants and …
[HTML][HTML] FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences
The sorting of RNA molecules to subcellular locations facilitates the activity of spatially
restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse …
restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse …
Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome
S Cherry, KW Lynch - Genes & Development, 2020 - genesdev.cshlp.org
Over the past decade there has been increased awareness of the potential role of
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …
[HTML][HTML] The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation
Background RNA-binding proteins (RBPs) function as master regulators of gene expression.
Alterations in RBP expression and function are often observed in cancer and influence …
Alterations in RBP expression and function are often observed in cancer and influence …
[HTML][HTML] Autism-misregulated eIF4G microexons control synaptic translation and higher order cognitive functions
T Gonatopoulos-Pournatzis, R Niibori, EW Salter… - Molecular cell, 2020 - cell.com
Microexons represent the most highly conserved class of alternative splicing, yet their
functions are poorly understood. Here, we focus on closely related neuronal microexons …
functions are poorly understood. Here, we focus on closely related neuronal microexons …