Technical review on the management of eosinophilic esophagitis: a report from the AGA institute and the joint task force on allergy-immunology practice parameters

MA Rank, RN Sharaf, GT Furuta, SS Aceves… - Annals of Allergy …, 2020 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus. Many
new studies have been reported recently that describe EoE management. An expert panel …

Non-IgE mediated food allergy

A Cianferoni - Current pediatric reviews, 2020 - ingentaconnect.com
Food allergies, defined as an immune response to food proteins, affect as many as 8% of
young children and 2% of adults in western countries, and their prevalence appears to be …

[HTML][HTML] Efficacy of dupilumab in a phase 2 randomized trial of adults with active eosinophilic esophagitis

I Hirano, ES Dellon, JD Hamilton, MH Collins… - Gastroenterology, 2020 - Elsevier
Background & Aims Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory
disease with no approved treatment in the United States. Dupilumab, a VelocImmune …

Emerging therapies for eosinophilic esophagitis

T Greuter, I Hirano, ES Dellon - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Despite advances in the pathologic understanding of eosinophilic esophagitis (EoE), as of
yet, no single agent has been approved by the US Food and Drug Administration to treat …

Duodenal inflammation: an emerging target for functional dyspepsia?

L Wauters, G Burns, M Ceulemans… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Functional dyspepsia (FD) is one of the most common functional
gastrointestinal disorders and is classified into postprandial distress and epigastric pain …

Phenotypes and endotypes in eosinophilic esophagitis

MA Ruffner, A Cianferoni - Annals of Allergy, Asthma & Immunology, 2020 - Elsevier
Objective To improve understanding of the heterogeneous presentation of eosinophilic
esophagitis (EoE), and its different potential phenotypes and endotypes. Data Sources We …

Eosinophilic esophagitis histology remission score: significant relations to measures of disease activity and symptoms

MH Collins, LJ Martin, T Wen, JP Abonia… - Journal of pediatric …, 2020 - journals.lww.com
Objectives: Eosinophilic esophagitis (EoE) is characterized by remissions and relapses.
Guidelines defining remission do not exist and therefore remission is inconsistently …

Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort

JLM Dunn, T Shoda, JM Caldwell, T Wen… - Journal of Allergy and …, 2020 - Elsevier
Background There is strong evidence for a role of type 2 cytokines in the pathogenesis of
eosinophilic esophagitis (EoE); however, heterogeneity in type 2 gene expression has not …

Eosinophils in eosinophilic esophagitis: the road to fibrostenosis is paved with good intentions

AD Doyle, MY Masuda, H Kita, BL Wright - Frontiers in immunology, 2020 - frontiersin.org
Eosinophilic esophagitis (EoE) is an antigen-driven disease associated with epithelial
barrier dysfunction and chronic type 2 inflammation. Eosinophils are the defining feature of …

Biologics for the treatment of allergic conditions: eosinophil disorders

B Olivieri, E Tinazzi, M Caminati… - … and Allergy Clinics, 2020 - immunology.theclinics.com
Eosinophil-associated diseases are characterized by a common pathogenetic background,
represented by eosinophilic inflammation and overexpression of IL-5. 1 Transgenic mice …