The role of polymorphonuclear neutrophils (PMNs) in biology is often recognized during
pathogenesis associated with PMN hyper-or hypo-functionality in various disease states …

Immune cells encounter tissues with vastly different biochemical and physical
characteristics. Much of the research emphasis has focused on the role of cytokines and …

Sepsis is conceptually defined as life-threatening organ dysfunction that is caused by a
dysregulated host response to infection. Although there has been significant advancement …

Leukocyte recruitment into inflamed tissue is highly dependent on the activation and binding
of integrins to their respective ligands, followed by the induction of various signaling events …

Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America and
may be caused by the species Paracoccidioides brasiliensis. In the lungs, this fungus …

Sepsis is a major challenge in clinical practice and responsible for high mortality. Recent
studies indicated that integrins participated in toll-like-receptor (TLR)-mediated innate …

Accumulation of hyperactive neutrophils in the visceral organs was shown to be associated
with sepsis-induced multi-organ failure. Recently, a C-terminal fragment of secreted …

Sepsis is a condition that dysregulates host immune response to infection causing life-
threatening organ dysfunction, which in turn contributes to the increased risk of mortality in …

Embodiments of the disclosure include methods and compositions for treating or preventing
acute inflammation using soluble vimentin. In specific embodiments, a vimentin derivative …