Strategies for developing κ opioid receptor agonists for the treatment of pain with fewer side effects
KF Paton, DV Atigari, S Kaska, T Prisinzano… - Journal of Pharmacology …, 2020 - ASPET
There is significant need to find effective, nonaddictive pain medications. κ Opioid receptor
(KOPr) agonists have been studied for decades but have recently received increased …
(KOPr) agonists have been studied for decades but have recently received increased …
Iron-catalyzed [3+ 2]-cycloaddition of in situ generated N-ylides with alkynes or olefins: access to multi-substituted/polycyclic pyrrole derivatives
K Zhou, M Bao, J Huang, Z Kang, X Xu… - Organic & Biomolecular …, 2020 - pubs.rsc.org
An iron-catalyzed one-pot three-component reaction of 1-substituted benzimidazoles with
diazoacetates and electron-deficient alkynes or alkenes has been reported. Mechanistically …
diazoacetates and electron-deficient alkynes or alkenes has been reported. Mechanistically …
[HTML][HTML] Crystal structure of 4-methyl-N-(4-methylbenzyl) benzenesulfonamide
BA Stenfors, RJ Staples, SM Biros… - Acta Crystallographica …, 2020 - scripts.iucr.org
The title compound, C15H17NO2S, was synthesized via a substitution reaction between 4-
methylbenzylamine and p-toluenesulfonyl chloride. In the crystal, N—H⋯ O hydrogen bonds …
methylbenzylamine and p-toluenesulfonyl chloride. In the crystal, N—H⋯ O hydrogen bonds …