Pathophysiological role and therapeutic implications of vitamin D in autoimmunity: focus on chronic autoimmune diseases

M Bellan, L Andreoli, C Mele, PP Sainaghi… - Nutrients, 2020 - mdpi.com
Vitamin D is a pleiotropic secosteroid yielding multiple actions in human physiology.
Besides the canonical regulatory activity on bone metabolism, several non-classical actions …

Age, gender and season are good predictors of vitamin D status independent of body mass index in office workers in a subtropical region

LK Wang, KC Hung, YT Lin, YJ Chang, ZF Wu, CH Ho… - Nutrients, 2020 - mdpi.com
This study aimed at determining the prevalence and predictors of hypovitaminosis D (serum
25-hydroxyvitamin D< 30 ng/mL) among office workers in a subtropical region from an …

The challenges of identifying environmental determinants of type 1 diabetes: in search of the holy grail

S Butalia, GG Kaplan, B Khokhar… - Diabetes, Metabolic …, 2020 - Taylor & Francis
Type 1 diabetes is the result of autoimmune-mediated destruction and inflammation of the
insulin-producing β-cells of the pancreas. The excess morbidity and mortality from its …

Evaluation of vitamin D metabolism in patients with type 1 diabetes mellitus in the setting of cholecalciferol treatment

A Povaliaeva, E Pigarova, A Zhukov, V Bogdanov… - Nutrients, 2020 - mdpi.com
In this prospective controlled study, we examined 25 adults with adequately controlled
(HbA1c level< 8.0%) type 1 diabetes mellitus (T1DM) and 49 conditionally healthy adults …

Low vitamin D levels predict mortality in ankylosing spondylitis patients: a nationwide population-based cohort study

N Ben-Shabat, A Watad, A Shabat, NL Bragazzi… - Nutrients, 2020 - mdpi.com
In this study, we aimed to examine the effect of vitamin D deficiency on all-cause mortality in
ankylosing spondylitis (AS) patients and in the general population. This is a retrospective …

Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement

EE Karaca, ÖE Kemer, D Özek, D Berker… - Arquivos Brasileiros de …, 2020 - SciELO Brasil
Purpose: To analyze the clinical outcomes of the ocular surface in patients with vitamin D
deficiency after oral replacement. Methods: A total of 40 patients with vitamin D deficiency …

Vitamin D Supplementation Modulates ICOS+ and ICOS− Regulatory T Cell in Siblings of Children With Type 1 Diabetes

S Savastio, F Cadario, S D'Alfonso… - The Journal of …, 2020 - academic.oup.com
Objectives Vitamin D plays an immunoregulatory activity. The aim of this study was to assess
the correlation between blood serum 25 (OH) D levels and Th17 and Treg circulating …

Vitamin D status and the immune assessment in 22q11. 2 deletion syndrome

A Legitimo, V Bertini, G Costagliola… - Clinical & …, 2020 - academic.oup.com
Summary 22q11. 2 deletion syndrome (22q11. 2DS) is characterized by a heterogeneous
phenotype, including alterations in phospho-calcium metabolism and immunodeficiency. We …

Microbiota, epidemiological and nutritional factors related to ketoacidosis at the onset of type 1 diabetes

I Rabbone, D Traversi, G Scaioli, C Vallini, G Carletto… - Acta Diabetologica, 2020 - Springer
Aims The incidence of type 1 diabetes has increased over the last decades. The
pathological pathway is not yet clear, even if genetic and environmental risk factors are …

The relationship of vitamin D status with the development and course of diabetes mellitus type 1

AA Povaliaeva, EA Pigarova… - Obesity and …, 2020 - omet-endojournals.ru
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease that develops as a result
of a genetic predisposition and environmental factors. Literature data indicate that the …