[HTML][HTML] Tetrahydrocurcumin ameliorates diabetes profiles of db/db mice by altering the composition of gut microbiota and up-regulating the expression of GLP-1 in the …

T Yuan, Z Yin, Z Yan, Q Hao, J Zeng, L Li, J Zhao - Fitoterapia, 2020 - Elsevier
Diabetes is a worldwide healthy concern, which affects approximately 9% of the population.
Tetrahydrocurcumin (THC) is the main metabolite of curcumin, which exerts the anti-diabetic …

Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β‐cell …

RA Lafferty, N Tanday, A McCloskey… - Diabetes, Obesity …, 2020 - Wiley Online Library
Aim To investigate the antidiabetic efficacy of enzymatically stable Peptide YY (PYY)
peptides from phylogenetically ancient fish. Materials and methods N‐terminally stabilized …

Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction

RA Lafferty, N Tanday, PR Flatt, N Irwin - Biochimica et Biophysica Acta …, 2020 - Elsevier
Abstract Background PYY (1–36) peptides from phylogenetically ancient fish, such as sea
lamprey, have previously been shown to function as specific neuropeptide Y1 receptor …

A long-acting, dual-agonist analogue of lamprey GLP-1 shows potent insulinotropic, β-cell protective, and anorexic activities and improves glucose homeostasis in …

GV Graham, A McCloskey, YH Abdel-Wahab… - Molecular and cellular …, 2020 - Elsevier
Peptidase-resistant analogues of GLP-1 peptides from sea lamprey and paddlefish ([D-Ala
2] palmitoyl-lamprey GLP-1 and [D-Ala 2] palmitoyl-paddlefish GLP-1) produced significant …

Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities

GV Graham, JM Conlon, YH Abdel-Wahab… - European Journal of …, 2020 - Elsevier
This study has examined the in vitro and in vivo anti-diabetic properties of the peptidase-
resistant analogues [D-Ser 2] palmitoyl-paddlefish glucagon and [D-Ser 2] palmitoyl-lamprey …

Modified gip peptide analogues

AH SPARRE-ULRICH, BB SIVERTSEN, D Riber… - 2020 - Google Patents
WO2020115049A1 - Modified gip peptide analogues - Google Patents WO2020115049A1 -
Modified gip peptide analogues - Google Patents Modified gip peptide analogues Download …