α7 nicotinic acetylcholine receptors as therapeutic targets in schizophrenia: Update on animal and clinical studies and strategies for the future
AV Terry Jr, PM Callahan - Neuropharmacology, 2020 - Elsevier
Schizophrenia is a devastating mental illness and its effective treatment is among the most
challenging issues in psychiatry. The symptoms of schizophrenia are heterogeneous …
challenging issues in psychiatry. The symptoms of schizophrenia are heterogeneous …
[HTML][HTML] Muscarinic M1 receptors modulate working memory performance and activity via KCNQ potassium channels in the primate prefrontal cortex
Working memory relies on the dorsolateral prefrontal cortex (dlPFC), where microcircuits of
pyramidal neurons enable persistent firing in the absence of sensory input, maintaining …
pyramidal neurons enable persistent firing in the absence of sensory input, maintaining …
Association of cognitive and P50 suppression deficits in chronic patients with schizophrenia
Objective Cognitive deficits are core symptoms of schizophrenia; however, their
pathophysiological mechanisms are still unclear. A sensory gating deficit, as reflected by …
pathophysiological mechanisms are still unclear. A sensory gating deficit, as reflected by …
Meta-analysis of randomized controlled trials of galantamine in schizophrenia: significant cognitive enhancement
Cognitive impairments are core features of schizophrenia and the best predictor of functional
outcome. Cholinergic system and alpha-7 nicotinic acetylcholine (α7nACh) receptors are …
outcome. Cholinergic system and alpha-7 nicotinic acetylcholine (α7nACh) receptors are …
[HTML][HTML] Schizophrenia in adults: Epidemiology and pathogenesis
BA Fischer, RW Buchanan - Waltham, MA: Wolters Kluwer, 2020 - medilib.ir
INTRODUCTION—Schizophrenia is among the most disabling and economically
catastrophic medical disorders. It is ranked by the World Health Organization as one of the …
catastrophic medical disorders. It is ranked by the World Health Organization as one of the …
GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired …
Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease
characterized by progressive airflow limitation, chronic respiratory symptoms and frequent …
characterized by progressive airflow limitation, chronic respiratory symptoms and frequent …
One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia
The core features of schizophrenia (SCZ) include cognitive deficits and impaired sensory
gating represented by P50 inhibition deficits, which appear to be related to the α7 nicotinic …
gating represented by P50 inhibition deficits, which appear to be related to the α7 nicotinic …
P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery
Objective Cognitive impairment is a core symptom of schizophrenia (SCZ); however, its
pathophysiological mechanisms remain unclear. The sensory gating (SG) deficits reflected …
pathophysiological mechanisms remain unclear. The sensory gating (SG) deficits reflected …
Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats
Schizophrenia is a common psychiatric disease that cannot be fully treated with current
antipsychotic drugs. It has shown that glutamatergic NMDA receptor antagonists such as MK …
antipsychotic drugs. It has shown that glutamatergic NMDA receptor antagonists such as MK …
A randomized clinical trial of oxytocin or galantamine in schizophrenia: assessing the impact on behavioral, lexical, and self-report indicators of social affiliation
KR Dwyer, AM Andrea, CLG Savage… - Schizophrenia …, 2020 - academic.oup.com
Prior studies examining the impact of oxytocin on negative symptoms in schizophrenia have
yielded mixed results. The current study explored whether oxytocin can improve more …
yielded mixed results. The current study explored whether oxytocin can improve more …