Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Cross-linking mass spectrometry (XL-MS) has matured into a potent tool to identify protein–
protein interactions or to uncover protein structures in living cells, tissues, or organelles. The …

Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including
heart disease, cancer, neurodegenerative diseases, and the general aging process …

Whole-cell cross-linking coupled to mass spectrometry is one of the few tools that can probe
protein–protein interactions in intact cells. A very attractive reagent for this purpose is …

For the last century we have relied on model organisms to help understand fundamental
biological processes. Now, with advancements in genome sequencing, assembly, and …

Just recently, chemical cross-linking combined with mass spectrometry (XL-MS) has
emerged as valuable tool to study protein interaction networks on the system-wide level. The …

Protein cross-linking and the analysis of cross-linked peptides by mass spectrometry is
currently receiving much attention. Not only is this approach applied to isolated complexes …

An experimental and computational approach for identification of protein-protein interactions
by ex vivo chemical crosslinking and mass spectrometry (CLMS) has been developed that …

Chemical cross-linking with mass spectrometry (XL-MS) has emerged as a useful tool for the
large-scale study of protein structures and interactions from complex biological samples …

Virology, as a branch of the life sciences, discovered mass spectrometry (MS) to be the
pivotal tool around two decades ago. The technique unveiled the complex network of …