Illuminating the noncoding genome in cancer
X Zhang, M Meyerson - Nature cancer, 2020 - nature.com
Understanding the mechanisms underlying tumorigenesis requires comprehensive
annotation of the cancer genome. The majority of the human genome consists of noncoding …
annotation of the cancer genome. The majority of the human genome consists of noncoding …
[HTML][HTML] lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling
J Pan, S Fang, H Tian, C Zhou, X Zhao, H Tian, J He… - Molecular cancer, 2020 - Springer
Abstract Background MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal
transition (EMT) in cancer cell dissemination are well established, but the involvement of …
transition (EMT) in cancer cell dissemination are well established, but the involvement of …
[HTML][HTML] Significance of single-nucleotide variants in long intergenic non-protein coding RNAs
H Zou, LX Wu, L Tan, FF Shang… - Frontiers in Cell and …, 2020 - frontiersin.org
Single-nucleotide variants (SNVs) are the most common genetic variants and universally
present in the human genome. Genome-wide association studies (GWASs) have identified a …
present in the human genome. Genome-wide association studies (GWASs) have identified a …
LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5
J Yuan, Y Song, W Pan, Y Li, Y Xu, M Xie, Y Shen… - Oncogene, 2020 - nature.com
Lymph node metastasis is the major adverse feature for recurrence and death of thyroid
cancer patients. To identify lncRNAs involved in thyroid cancer metastasis, we systemically …
cancer patients. To identify lncRNAs involved in thyroid cancer metastasis, we systemically …
SMAD3/SP1 complex‐mediated constitutive active loop between lncRNA PCAT7 and TGF‐β signaling promotes prostate cancer bone metastasis
Bone metastasis is associated with cancer‐related death in patients with prostate cancer
(PCa). Long noncoding RNAs (lncRNAs) play critical roles in tumor progression of PCa …
(PCa). Long noncoding RNAs (lncRNAs) play critical roles in tumor progression of PCa …
Genetic variants in m6A modification genes are associated with colorectal cancer risk
Abstract The N6-methyladenosine (m6A) modification plays important regulatory roles in
gene expression, cancer occurrence and metastasis. Herein, we aimed to explore the …
gene expression, cancer occurrence and metastasis. Herein, we aimed to explore the …
LncRNA LINC00665 promotes prostate cancer progression via miR-1224-5p/SND1 axis
W Chen, Z Yu, W Huang, Y Yang, F Wang… - OncoTargets and …, 2020 - Taylor & Francis
Background Increasing researches have revealed a critical role of long noncoding RNAs
(lncRNAs) in tumor progression. LINC00665 is a poorly investigated lncRNA. In this …
(lncRNAs) in tumor progression. LINC00665 is a poorly investigated lncRNA. In this …
The role of noncoding variants in heritable disease
JD French, SL Edwards - Trends in Genetics, 2020 - cell.com
The genetic basis of disease has largely focused on coding regions. However, it has
become clear that a large proportion of the noncoding genome is functional and harbors …
become clear that a large proportion of the noncoding genome is functional and harbors …
lncRNA Neat1 stimulates osteoclastogenesis via sponging miR‐7
Y Zhang, XF Chen, J Li, F He, X Li… - Journal of Bone and …, 2020 - Wiley Online Library
Increasing evidence uncover the essential role of long noncoding RNA (lncRNAs) in bone
metabolism and the association of lncRNA with genetic risk of osteoporosis. However …
metabolism and the association of lncRNA with genetic risk of osteoporosis. However …
ERINA Is an Estrogen-Responsive LncRNA That Drives Breast Cancer through the E2F1/RB1 Pathway
Resistance to therapeutic drugs is a major challenge in the treatment of cancers, including
breast cancer. Long noncoding RNAs (lncRNA) are known to have diverse physiologic and …
breast cancer. Long noncoding RNAs (lncRNA) are known to have diverse physiologic and …