Targeted protein degradation (TPD) has emerged as an exciting new era in chemical
biology and drug discovery. PROteolysis TArgeting Chimera (PROTAC) technology targets …

Blocking the biological functions of scaffold proteins and aggregated proteins is a
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …

Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-
dependent degradation of proteins. TPD is of interest in drug development, as it can address …

PROTACs (PROteolysis TArgeting Chimeras) are bifunctional molecules that target proteins
for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome …

Chemical biology strategies for directly perturbing protein homeostasis including the
degradation tag (dTAG) system provide temporal advantages over genetic approaches and …

Abstract Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules
that can promote the rapid and selective proteasome-mediated degradation of intracellular …

Proteolysis targeting chimeras (PROTACs) represent an exciting inhibitory modality with
many advantages, including substoichiometric degradation of targets. Their scope, though …

Controlled perturbation of protein activity is essential to study protein function in cells and
living organisms. Small molecules that hijack the cellular protein ubiquitination machinery to …

Two decades into the twenty-first century, a confluence of breakthrough technologies
wielded at the molecular level is presenting biologists with unique opportunities to unravel …

Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focus on choosing
an appropriate E3 ligase for the target protein, improving the binding affinities towards the …