[HTML][HTML] Carbapenem-sparing strategies for ESBL producers: when and how

I Karaiskos, H Giamarellou - Antibiotics, 2020 - mdpi.com
Extended spectrum β-lactamase (ESBL)-producing bacteria are prevalent worldwide and
correlated with hospital infections, but they have been evolving as an increasing cause of …

[PDF][PDF] Infectious diseases society of america antimicrobial resistant treatment guidance: gram-negative bacterial infections

PD Tamma, SL Aitken, RA Bonomo, AJ Mathers… - practice, 2020 - kduoc.duytan.edu.vn
The rise in antimicrobial resistance (AMR) continues to be a global crisis [1, 2]. Collectively,
antimicrobial resistant pathogens caused more than 2.8 million infections and over 35,000 …

Plazomicin: an intravenous aminoglycoside antibacterial for the treatment of complicated urinary tract infections

A Bilinskaya, KE Linder, JL Kuti - Expert Review of Anti-infective …, 2020 - Taylor & Francis
Introduction Antimicrobial resistance continues to be a major public health concern due to
the emergence and spread of multi-drug resistant (MDR) organisms, including extended …

[HTML][HTML] Clinical experience with ceftazidime-avibactam for the treatment of infections due to multidrug-resistant Gram-negative bacteria other than carbapenem …

A Vena, DR Giacobbe, N Castaldo, A Cattelan… - Antibiotics, 2020 - mdpi.com
Background: Experience in real clinical practice with ceftazidime-avibactam for the treatment
of serious infections due to gram− negative bacteria (GNB) other than carbapenem-resistant …

Is piperacillin-tazobactam effective for the treatment of pyelonephritis caused by extended-spectrum β-lactamase–producing organisms?

SL Sharara, J Amoah, ZD Pana… - Clinical Infectious …, 2020 - academic.oup.com
Background Limited data exist regarding the efficacy of piperacillin-tazobactam (TZP) for the
management of nonbacteremic pyelonephritis caused by extended-spectrum β-lactamase …

Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill …

L Caro, DP Nicolau, JJ De Waele, JL Kuti… - Journal of …, 2020 - academic.oup.com
Objectives Ceftolozane/tazobactam is approved for hospital-acquired/ventilator-associated
bacterial pneumonia at double the dose (ie 2 g/1 g) recommended for other indications. We …

[HTML][HTML] Fourth Generation Cephalosporin Resistance Among Salmonella enterica Serovar Enteritidis Isolates in Shanghai, China Conferred by blaCTX–M–55 …

Y Fu, X Xu, L Zhang, Z Xiong, Y Ma, Y Wei… - Frontiers in …, 2020 - frontiersin.org
In this study, we investigated the pattern of antimicrobial resistance in Salmonella enterica
serotype Enteritidis isolates in Shanghai, China from 2005 to 2014. We found the first …

[HTML][HTML] Molecular Characterization of Extended-Spectrum β-Lactamase–Producing Escherichia coli and Klebsiella pneumoniae Among the Pediatric Population in …

A Perez-Lopez, S Sundararaju, H Al-Mana… - Frontiers in …, 2020 - frontiersin.org
Introduction Although extended-spectrum β-lactamase (ESBL)–producing Enterobacterales
are a public health problem in the Arabian Peninsula, data on the molecular characteristic of …

In vitro activity of ceftolozane/tazobactam against phenotypically defined extended-spectrum β-lactamase (ESBL)-positive isolates of Escherichia coli and Klebsiella …

JA Karlowsky, KM Kazmierczak, K Young… - … and Infectious Disease, 2020 - Elsevier
Abstract The Clinical and Laboratory Standards Institute (CLSI)-defined broth microdilution
testing method (M07, 11th edition, 2018) was used to determine MICs for ceftolozane …

Pharmacokinetics-pharmacodynamics of enmetazobactam combined with cefepime in a neutropenic murine thigh infection model

F Bernhard, R Odedra, S Sordello… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
ABSTRACT Third-generation cephalosporin (3GC)-resistant Enterobacteriaceae are
classified as critical priority pathogens, with extended-spectrum β-lactamases (ESBLs) as …