Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

Polyunsaturated fatty acids (n-3 PUFAs) are long-chain polyunsaturated fatty acids with 18,
20 or 22 carbon atoms, which have been found able to counteract cardiovascular diseases …

Hypertension prevalence increases with age. Age and high blood pressure are the two main
determinants of arterial stiffness. In elderly hypertensives, large arteries stiffen and systolic …

Tumors are influenced by the mechanical properties of their microenvironment. Using
patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver …

Despite the wide recognition of larger artery stiffness as a highly clinically relevant and
independent prognostic biomarker, it has yet be incorporated into routine clinical practice …

Inflammation is a physiological response to aggression of pathogenic agents aimed at
eliminating the aggressor agent and promoting healing. Excessive inflammation, however …

Arterial stiffness is a major independent risk factor for cardiovascular complications causing
isolated systolic hypertension and increased pulse pressure in the microvasculature of …

With increasing age, the cardiovascular risk increases, as does frailty, with negative health
consequences such as coronary disease, stroke, and vascular dementia. However, this …

Phenotypic polarization of macrophages is deemed essential in innate immunity and various
pathophysiological conditions. We have now determined key aspects of the molecular …

BACKGROUND Arterial stiffness—typically assessed from non-invasive measurement of
pulse wave velocity along a straight portion of the vascular tree between the right common …