[HTML][HTML] Passenger mutations in more than 2,500 cancer genomes: overall molecular functional impact and consequences
The dichotomous model of" drivers" and" passengers" in cancer posits that only a few
mutations in a tumor strongly affect its progression, with the remaining ones being …
mutations in a tumor strongly affect its progression, with the remaining ones being …
[HTML][HTML] Candidate cancer driver mutations in distal regulatory elements and long-range chromatin interaction networks
A comprehensive catalog of cancer driver mutations is essential for understanding
tumorigenesis and developing therapies. Exome-sequencing studies have mapped many …
tumorigenesis and developing therapies. Exome-sequencing studies have mapped many …
Powerful rare variant association testing in a copula‐based joint analysis of multiple phenotypes
S Konigorski, YE Yilmaz, J Janke… - Genetic …, 2020 - Wiley Online Library
In genetic association studies of rare variants, the low power of association tests is one of
the main challenges. In this study, we propose a new single‐marker association test called …
the main challenges. In this study, we propose a new single‐marker association test called …
Predictive and patient-monitoring biomarkers: precision in the management of colorectal cancer
G Pappas-Gogos, EG Baltagiannis… - Biomarkers in …, 2020 - Taylor & Francis
Development of noninvasive screening and biomarkers to precisely predict drug response in
individual patients with colorectal cancer (CRC) represents an emerging goal of …
individual patients with colorectal cancer (CRC) represents an emerging goal of …
Precision in cancer pharmacogenomics
ID Kyrochristos, EG Baltagiannis, M Mitsis… - …, 2020 - Taylor & Francis
Progress in cancer treatment on the basis of conventional technologies and research
remains slow, as reflected by the high rates of drug resistance, relapse and death [1, 2]. The …
remains slow, as reflected by the high rates of drug resistance, relapse and death [1, 2]. The …