The immunological basis of liver allograft rejection

V Ronca, G Wootton, C Milani, O Cain - Frontiers in immunology, 2020 - frontiersin.org
Liver allograft rejection remains a significant cause of morbidity and graft failure in liver
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …

Organ utilization–the next hurdle in transplantation?

J Neuberger, C Callaghan - Transplant International, 2020 - Wiley Online Library
Nonutilization of organs from consented deceased donors remains a significant factor in
limiting patient access to transplantation. Critical to reducing waste is a clear understanding …

Viability criteria assessment during liver machine perfusion

IMA Brüggenwirth, VE de Meijer, RJ Porte… - Nature …, 2020 - nature.com
Mergental et al. 2 No Within 3 h of NMP:(1) perfusate lactate must be< 2.5 mmol l–l or the
liver must produce bile;(2) other criteria:(i) perfusate pH> 7.30;(ii) hepatic artery flow> 150 ml …

Viability testing of discarded livers with normothermic machine perfusion: alleviating the organ shortage outweighs the cost

S Raigani, RJ De Vries, C Carroll… - Clinical …, 2020 - Wiley Online Library
Background Over 700 donor livers are discarded annually in the United States due to high
risk of poor graft function. The objective of this study was to determine the impact of using …

The myths and realities of portopulmonary hypertension

HM DuBrock, MJ Krowka - Hepatology, 2020 - journals.lww.com
Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor... : Hepatology Immune‐Responsive
Gene 1/Itaconate Activates Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocytes to …

Preventing tumour recurrence after liver transplantation: the role of machine perfusion

Y Boteon, MA Flores Carvalho, R Panconesi… - International Journal of …, 2020 - mdpi.com
Tumour recurrence is currently a hot topic in liver transplantation. The basic mechanisms are
increasingly discussed, and, for example, recurrence of hepatocellular carcinoma is often …

Strategies in organ preservation—a new golden age

PJ Friend - Transplantation, 2020 - journals.lww.com
In this issue of Transplantation, attention is focused on a perennial challenge, organ
preservation and its associated ischemia-reperfusion injury (IRI). The interview of Dr James …

[HTML][HTML] Principles and current status of abdominal organ preservation for transplantation

SH Abbas, PJ Friend - Surgery in Practice and Science, 2020 - Elsevier
Solid organ transplantation provides a definitive treatment for end-stage organ failure. The
clinical field has progressed rapidly since its early beginnings during the latter half of the …

[PDF][PDF] Long‐Term Perfusion of the Liver Outside the Body: Warming Up for Ex Vivo Therapies?

IJ Schurink, J Willemse, MMA Verstegen… - …, 2020 - Wiley Online Library
2) Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, et al. Global chemical
effects of the microbiome include new bileacid conjugations. Nature 2020; 579: 123-129. 3) …

中重度脂肪变性供肝应用于成人肝移植术的早期预后及其危险因素分析.

田大治, 蒋文涛, 陈池义, 于杨… - … Transplantation/Qi Guan …, 2020 - search.ebscohost.com
目的探讨中重度脂肪变性供肝肝移植受者的早期预后及其发生移植物功能延迟恢复(DGF)
的危险因素. 方法回顾性分析公民逝世后器官捐献供肝肝移植供, 受者各475 例的临床资料 …