Bacteria sense and respond to their environment through a highly conserved assembly of
transmembrane chemoreceptors (MCPs), the histidine kinase CheA, and the coupling …

Chemotaxis is crucial for the survival of bacteria, and the signaling systems associated with
it exhibit a high level of evolutionary conservation. The architecture of the chemosensory …

How complex, multi-component macromolecular machines evolved remains poorly
understood. Here we reveal the evolutionary origins of the chemosensory machinery that …

Vibrio cholerae, the causative agent of the acute diarrheal disease cholera, is able to thrive
in diverse habitats such as natural water bodies and inside human hosts. To ensure their …

Bacteria have evolved complex sensing and signaling systems to react to their changing
environments, most of which are present in all domains of life. Canonical bacterial sensing …

The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in
biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 …

Cells require a sensory system and a motility structure to achieve directed movement.
Bacteria and archaea possess rotating filamentous motility structures that work in concert …

Pentameric ligand-gated ion channels (pLGICs) are allosteric receptors that mediate rapid
electrochemical signal transduction in the animal nervous system through the opening of an …

Salmonella enterica is the most frequently reported cause of foodborne illness. As in other
microorganisms, chemotaxis affords key physiological benefits, including enhanced access …

Visualizing biological structures and cellular processes in their native state is a major goal of
many scientific laboratories. In the past 20 years, the technique of preserving samples by …