Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Among antioxidants in the human body, bilirubin has been recognized over the past 20
years to afford protection against different chronic conditions, including inflammation and …

Cigarette smoke is a complex mixture capable of triggering inflammation and oxidative
damage in animals at pulmonary and systemic levels. Tempol (4-hydroxy-2, 2, 6, 6 …

While intrinsic changes in aging hematopoietic stem cells (HSCs) are well characterized, it
remains unclear how extrinsic factors affect HSC aging. Here, we demonstrate that cells in …

The physiopathology of pulmonary arterial hypertension (PAH) is characterized by
pulmonary artery smooth muscle cell (PASMC) and endothelial cell (PAEC) dysfunction …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by complex
pathological and biological features. Notably, extracellular amyloid-β deposits as senile …

Background Preeclampsia is a common obstetric syndrome affecting women in their first
pregnancy and characterized by hypertension and proteinuria, which appears after 20 …

Progression of chronic kidney disease (CKD) involves the recruitment and engagement of
cellular processes originating in specific compartments of the kidney on the one hand and …

Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

The enzyme heme oxygenase-1 (HO-1), encoded by the HMOX1 gene, mediates heme
catabolism by cleaving free heme. We have previously revealed the importance of HO-1 in …