PAICS, a purine nucleotide metabolic enzyme, is involved in tumor growth and the metastasis of colorectal cancer
S Agarwal, BVSK Chakravarthi, M Behring, HG Kim… - Cancers, 2020 - mdpi.com
The identification of colorectal cancer (CRC) molecular targets is needed for the
development of drugs that improve patient survival. We investigated the functional role of …
development of drugs that improve patient survival. We investigated the functional role of …
[HTML][HTML] Targeting P4HA1 with a small molecule inhibitor in a colorectal cancer PDX model
Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and
metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha …
metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha …
TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status
S Agarwal, M Behring, HG Kim… - Molecular …, 2020 - Wiley Online Library
Overexpression of TRIP13, a member of the AAA‐ATPase family, is linked with various
cancers, but its role in metastasis is unknown in colorectal cancer (CRC). In the current …
cancers, but its role in metastasis is unknown in colorectal cancer (CRC). In the current …
[HTML][HTML] PAICS, a de novo purine biosynthetic enzyme, is overexpressed in pancreatic cancer and is involved in its progression
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with an extremely poor
prognosis. There is an urgent need to identify new therapeutic targets and also understand …
prognosis. There is an urgent need to identify new therapeutic targets and also understand …
9G TestTM Cancer/Lung: A Desirable Companion to LDCT for Lung Cancer Screening
W Choe, JD Chae, BH Lee, SH Kim, SY Park… - Cancers, 2020 - mdpi.com
Simple Summary Lung cancer is the most common cause of cancer-related deaths globally.
Patients diagnosed at early-stage (0–I) have a higher survival rate than the metastasized …
Patients diagnosed at early-stage (0–I) have a higher survival rate than the metastasized …
Metastasis: a major driver of cancer pathogenesis
Cancer is a multifactorial condition that originates from genomic alterations in the cells,
which confer them the ability to evade various cellular regulations and proliferate …
which confer them the ability to evade various cellular regulations and proliferate …