[HTML][HTML] The molecular adaptive responses of skeletal muscle to high-intensity exercise/training and hypoxia

J Li, Y Li, MM Atakan, J Kuang, Y Hu, DJ Bishop, X Yan - Antioxidants, 2020 - mdpi.com
High-intensity exercise/training, especially interval exercise/training, has gained popularity
in recent years. Hypoxic training was introduced to elite athletes half a century ago and has …

Sport and exercise genomics: the FIMS 2019 consensus statement update

K Tanisawa, G Wang, J Seto, I Verdouka… - British journal of sports …, 2020 - bjsm.bmj.com
Rapid advances in technologies in the field of genomics such as high throughput DNA
sequencing, big data processing by machine learning algorithms and gene-editing …

An epigenetic clock for human skeletal muscle

S Voisin, NR Harvey, LM Haupt… - Journal of cachexia …, 2020 - Wiley Online Library
Background Ageing is associated with DNA methylation changes in all human tissues, and
epigenetic markers can estimate chronological age based on DNA methylation patterns …

[HTML][HTML] Effect of ACTN3 Genotype on Sports Performance, Exercise-Induced Muscle Damage, and Injury Epidemiology

G Baltazar-Martins, J Gutiérrez-Hellín… - Sports, 2020 - mdpi.com
Genetic factors play a significant role in athletic performance and its related phenotypes
such as power, strength and aerobic capacity. In this regard, the lack of a muscle protein due …

[HTML][HTML] Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study

M Jacques, J Kuang, DJ Bishop, X Yan… - The FASEB …, 2020 - ncbi.nlm.nih.gov
Mitochondrial respiration using the oxygraph‐2k respirometer (Oroboros) is widely used to
estimate mitochondrial capacity in human skeletal muscle. Here, we measured …

[HTML][HTML] Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan

D Hiam, C Smith, S Voisin, J Denham, X Yan… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
A reduction in aerobic capacity and the shortening of telomeres are hallmarks of the ageing
process. We examined whether a lower aerobic capacity is associated with shorter TL in …

Genetic variants associated with exercise performance in both moderately trained and highly trained individuals

NR Harvey, S Voisin, PJ Dunn, H Sutherland… - Molecular Genetics and …, 2020 - Springer
Adaptation to exercise training is a complex trait that may be influenced by genetic variants.
We identified 36 single nucleotide polymorphisms (SNPs) that had been previously …

[HTML][HTML] Investigating the influence of mtDNA and nuclear encoded mitochondrial variants on high intensity interval training outcomes

NR Harvey, S Voisin, RA Lea, X Yan, MC Benton… - Scientific Reports, 2020 - nature.com
Mitochondria supply intracellular energy requirements during exercise. Specific
mitochondrial haplogroups and mitochondrial genetic variants have been associated with …

[PDF][PDF] Updated evidence report for the anti-doping research: Analysis from 2008 to 2018 for performance-enhancing drugs and gene doping test development

F Mazzeo, S Santamaria, P Montesano, M Rinaldi… - J. Phys. Ed. Sport, 2020 - efsupit.ro
Introduction: Since ancient times, man has always tried to overcome his skills through the
use of substances and drugs whose nature has changed over time. From substances of …

Statistical considerations and biological mechanisms underlying individual differences in adaptations to exercise training

JT Bonafiglia, H Islam, N Eynon… - The Routledge Handbook …, 2020 - taylorfrancis.com
There is a growing interest in examining interindividual differences in adaptations to
exercise training and classifying individuals as “responders” or “low-responders.” Despite …