Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …

Background Whether respiratory physiology of COVID-19-induced respiratory failure is
different from acute respiratory distress syndrome (ARDS) of other etiologies is unclear. We …

In 2019, the United States experienced an unprecedented outbreak of electronic cigarette (e-
cigarette), or vaping, product use–associated lung injury (EVALI)(1–4). Although reports of …

Background Postextubation high-flow nasal cannula (HFNC) is used as a support therapy in
high-risk patients in ICU. This study aimed to determine the effects of HFNC therapy on lung …

Pulmonary inflammation is a hallmark of several pulmonary disorders including acute lung
injury and acute respiratory distress syndrome. Moreover, it has been shown that patients …

Intravital microscopy (IVM) offers unique possibilities for the observation of biological
processes and disease related mechanisms in vivo. Especially for anatomically complex …

Background Respiratory diseases are one of the leading causes of death worldwide, yet
effective treatment options remain limited. Although inflammation is thought to be a key …

Background Pulmonary atelectasis is frequent in clinical settings. Yet there is limited
mechanistic understanding and substantial clinical and biologic controversy on its …

With great interest, we read the article by van der Zee and colleagues suggesting an
individualized approach for setting the correct amount of positive end-expiratory pressure …

Increased pulmonary lactate production is correlated with severity of lung injury and
outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted …