[HTML][HTML] Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
Deciphering the shared genetic basis of distinct cancers has the potential to elucidate
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …
[HTML][HTML] Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …
[HTML][HTML] Tracking the genetic susceptibility background of B-cell non-Hodgkin's lymphomas from genome-wide association studies
I Hernández-Verdin, K Labreche, M Benazra… - International journal of …, 2020 - mdpi.com
B-cell non-Hodgkin's lymphoma (NHL) risk associations had been mainly attributed to family
history of the disease, inflammation, and immune components including human leukocyte …
history of the disease, inflammation, and immune components including human leukocyte …
[HTML][HTML] Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never …
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung
adenocarcinoma development among never-smokers using TB genome-wide association …
adenocarcinoma development among never-smokers using TB genome-wide association …
Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing …
MJ Bray, LS Chen, L Fox, DB Hancock… - Genetic …, 2020 - Wiley Online Library
Smoking is a major contributor to lung cancer and chronic obstructive pulmonary disease
(COPD). Two of the strongest genetic associations of smoking‐related phenotypes are the …
(COPD). Two of the strongest genetic associations of smoking‐related phenotypes are the …
Genome‐wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk
Genome‐wide association studies (GWAS) have identified 45 susceptibility loci associated
with lung cancer. Only less than SNPs, small insertions and deletions (INDELs) are the …
with lung cancer. Only less than SNPs, small insertions and deletions (INDELs) are the …
[HTML][HTML] Cross-cancer pleiotropic analysis reveals novel susceptibility loci for lung cancer
L Wang, M Zhu, Y Wang, J Fan, Q Sun, M Ji… - Frontiers in …, 2020 - frontiersin.org
Genome-wide association studies (GWASs) have identified hundreds of single nucleotide
polymorphisms (SNPs) associated with cancer risk, several of which have shown pleiotropic …
polymorphisms (SNPs) associated with cancer risk, several of which have shown pleiotropic …
Harnessing population pedigree data and machine learning methods to identify patterns of familial bladder cancer risk
Background: Relatives of patients with bladder cancer have been shown to be at increased
risk for kidney, lung, thyroid, and cervical cancer after correcting for smoking-related …
risk for kidney, lung, thyroid, and cervical cancer after correcting for smoking-related …
Association Analysis of Driver Gene–Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls
Y Wang, OY Gorlova, IP Gorlov, M Zhu, J Dai… - … Biomarkers & Prevention, 2020 - AACR
Background: A substantial proportion of cancer driver genes (CDG) are also cancer
predisposition genes. However, the associations between genetic variants in lung CDGs …
predisposition genes. However, the associations between genetic variants in lung CDGs …
Trans-ethnic genome-wide meta-analysis of 35,732 cases and 34,424 controls identifies novel genomic cross-ancestry loci contributing to lung cancer susceptibility
Lung cancer is the leading cause of cancer death worldwide. Genome-wide association
studies have revealed genetic risk factors, highlighting the role of smoking, family history …
studies have revealed genetic risk factors, highlighting the role of smoking, family history …