[HTML][HTML] Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

SR Rashkin, RE Graff, L Kachuri, KK Thai… - Nature …, 2020 - nature.com
Deciphering the shared genetic basis of distinct cancers has the potential to elucidate
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …

[HTML][HTML] Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

YD Zhang, AN Hurson, H Zhang, PP Choudhury… - Nature …, 2020 - nature.com
Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …

[HTML][HTML] Tracking the genetic susceptibility background of B-cell non-Hodgkin's lymphomas from genome-wide association studies

I Hernández-Verdin, K Labreche, M Benazra… - International journal of …, 2020 - mdpi.com
B-cell non-Hodgkin's lymphoma (NHL) risk associations had been mainly attributed to family
history of the disease, inflammation, and immune components including human leukocyte …

[HTML][HTML] Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never …

JYY Wong, H Zhang, CA Hsiung, K Shiraishi, K Yu… - Genomics, 2020 - Elsevier
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung
adenocarcinoma development among never-smokers using TB genome-wide association …

Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing …

MJ Bray, LS Chen, L Fox, DB Hancock… - Genetic …, 2020 - Wiley Online Library
Smoking is a major contributor to lung cancer and chronic obstructive pulmonary disease
(COPD). Two of the strongest genetic associations of smoking‐related phenotypes are the …

Genome‐wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk

J Dai, M Huang, CI Amos, RJ Hung… - … Journal of Cancer, 2020 - Wiley Online Library
Genome‐wide association studies (GWAS) have identified 45 susceptibility loci associated
with lung cancer. Only less than SNPs, small insertions and deletions (INDELs) are the …

[HTML][HTML] Cross-cancer pleiotropic analysis reveals novel susceptibility loci for lung cancer

L Wang, M Zhu, Y Wang, J Fan, Q Sun, M Ji… - Frontiers in …, 2020 - frontiersin.org
Genome-wide association studies (GWASs) have identified hundreds of single nucleotide
polymorphisms (SNPs) associated with cancer risk, several of which have shown pleiotropic …

Harnessing population pedigree data and machine learning methods to identify patterns of familial bladder cancer risk

HA Hanson, CL Leiser, B O'neil, C Martin… - … Biomarkers & Prevention, 2020 - AACR
Background: Relatives of patients with bladder cancer have been shown to be at increased
risk for kidney, lung, thyroid, and cervical cancer after correcting for smoking-related …

Association Analysis of Driver Gene–Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls

Y Wang, OY Gorlova, IP Gorlov, M Zhu, J Dai… - … Biomarkers & Prevention, 2020 - AACR
Background: A substantial proportion of cancer driver genes (CDG) are also cancer
predisposition genes. However, the associations between genetic variants in lung CDGs …

Trans-ethnic genome-wide meta-analysis of 35,732 cases and 34,424 controls identifies novel genomic cross-ancestry loci contributing to lung cancer susceptibility

J Byun, Y Han, Y Li, J Xia, X Xiao, R Sun, KM Walsh… - medRxiv, 2020 - medrxiv.org
Lung cancer is the leading cause of cancer death worldwide. Genome-wide association
studies have revealed genetic risk factors, highlighting the role of smoking, family history …