Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Genetics and epigenetics of atopic dermatitis: an updated systematic review

MJ Martin, M Estravís, A García-Sánchez, I Dávila… - Genes, 2020 - mdpi.com
Background: Atopic dermatitis is a common inflammatory skin disorder that affects up to 15–
20% of the population and is characterized by recurrent eczematous lesions with intense …

Exosome-mediated transfer of anti-miR-33a-5p from transduced endothelial cells enhances macrophage and vascular smooth muscle cell cholesterol efflux

A Stamatikos, E Knight, L Vojtech, L Bi… - Human gene …, 2020 - liebertpub.com
Atherosclerosis is a disease of large-and medium-sized arteries that is caused by
cholesterol accumulation in arterial intimal cells, including macrophages and smooth muscle …

METTL3 induces AAA development and progression by modulating N6-methyladenosine-dependent primary miR34a processing

L Zhong, X He, H Song, Y Sun, G Chen, X Si… - … Therapy-Nucleic Acids, 2020 - cell.com
Identifying effective drugs to delay the progression of aortic aneurysms is a formidable
challenge in vascular medicine. Methyltransferase-like 3 (METTL3) plays a key role in …

Exosome-derived MiRNAs as biomarkers of the development and progression of intracranial aneurysms

B Liao, M Zhou, F Zhou, X Luo, S Zhong… - … of atherosclerosis and …, 2020 - jstage.jst.go.jp
Aim: Exosome-derived microRNAs (miRNAs) are potential diagnostic biomarkers. However,
little is known about their effectiveness as diagnostic biomarkers of intracranial aneurysms …

[HTML][HTML] Long noncoding RNAs in key cellular processes involved in aortic aneurysms

Z Wu, M Trenner, RA Boon, JM Spin, L Maegdefessel - Atherosclerosis, 2020 - Elsevier
Aortic aneurysm (AA) is a complex and dangerous vascular disease, featuring progressive
and irreversible vessel dilatation. AA is typically detected either by screening, or identified …

Genetic and epigenetic regulation of abdominal aortic aneurysms

KD Mangum, MA Farber - Clinical genetics, 2020 - Wiley Online Library
Abdominal aortic aneurysms (AAAs) are focal dilations of the aorta that develop from
degenerative changes in the media and adventitia of the vessel. Ruptured AAAs have a …

Identification of novel microRNA profiles dysregulated in plasma and tissue of abdominal aortic aneurysm patients

E Plana, L Gálvez, P Medina, S Navarro… - International Journal of …, 2020 - mdpi.com
microRNAs (miRNAs) are small RNAs that regulate different biological processes. Our
objective was to identify miRNAs dysregulated in plasma and tissue of patients with …

Collagen fibril abnormalities in human and mice abdominal aortic aneurysm

B Jones, JR Tonniges, A Debski, B Albert, DA Yeung… - Acta biomaterialia, 2020 - Elsevier
Vascular diseases like abdominal aortic aneurysms (AAA) are characterized by a drastic
remodeling of the vessel wall, accompanied with changes in the elastin and collagen …

miR-29a promotes the neurite outgrowth of rat neural stem cells by targeting extracellular matrix to repair brain injury

R Ma, M Wang, S Gao, L Zhu, L Yu, D Hu… - Stem Cells and …, 2020 - liebertpub.com
Neural stem cells (NSCs) can generate new neurons to repair brain injury and central
nervous system disease by promoting neural regeneration. MicroRNAs (miRNAs) involve in …