Muscle has conventionally been viewed as a motor that converts chemical to kinetic energy
in series with a passive spring, but new insights emerge when muscle is viewed as a …

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterised by
ventricular arrhythmia and an increased risk of sudden cardiac death (SCD). Numerous …

Gaps in our understanding of muscle mechanics demonstrate that the current model is
incomplete. Increasingly, it appears that a role for titin in active muscle contraction might …

Alternative splicing is a regulatory mechanism essential for cell differentiation and tissue
organization. More than 90% of human genes are regulated by alternative splicing events …

The active isometric force produced by muscles varies with muscle length in accordance
with the force–length relationship. Compared with isometric contractions at the same final …

Cardiomyocytes are the motor units that drive the contraction and relaxation of the heart.
Traditionally, testing of drugs for cardiotoxic effects has relied on primary cardiomyocytes …

Key points Fast sarcomere‐level mechanics in contracting intact fibres from frog skeletal
muscle reveal an I‐band spring with an undamped stiffness 100 times larger than the known …

This study assessed the regional changes in myocardial geometry, microstructure,
mechanical behavior, and properties that occur in response to progressive left ventricular …

Subchronic intoxications induced in male rats by repeated intraperitoneal injections of lead
acetate and cadmium chloride, administered either alone or in combination, are shown to …

Abstract Aims Increased Ankyrin Repeat Domain 1 (ANKRD1) levels linked to gain of
function mutations have been associated to total anomalous pulmonary venous return and …