Quercetin (Que) and its derivatives are naturally occurring phytochemicals with promising
bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti …

Oxidative stress reflects an imbalance between the production of reactive oxygen species
(ROS) and antioxidant defense systems, and it can be associated with the pathogenesis and …

Sweet and bitter oranges are two of the most commercially-important fruit with a total world
production of 75.4 Mt, well-recognized for their unique sensory characters in addition to …

Multiple lines of evidence have shown that neuroinflammation and autophagy are highly
involved in the process of depression. Nobiletin (NOB) displays neuroprotective effects and …

Podocyte injury inevitably results in leakage of proteins from the glomerular filter and is vital
in the pathogenesis of diabetic nephropathy (DN). The underlying mechanisms of podocyte …

Epithelial-mesenchymal transition (EMT) constitutes one of the hallmarks of carcinogenesis
consisting in the re-differentiation of the epithelial cells into mesenchymal ones changing the …

In order to discover the active anti-tumor ingredients during the flavonoids separation
process of Ougan (Citrus reticulata cv. Suavissima), gastric cancer cell lines including AGS …

Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary
diseases and is accountable for post-traumatic wound infections, lymphadenitis …

Nobiletin, a polymethoxy flavone (PMF), is specific to citrus and has been reported to exhibit
important health-supporting properties. Nobiletin has six methoxy groups at the 3′, 4′, 5 …

Background Tangeretin, a flavonoid derived from citrus peel, showed anti-diabetic effects.
However, the role of tangeretin on liver, the organ that act as target of insulin and play the …