Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

The controversial role of human gut lachnospiraceae

M Vacca, G Celano, FM Calabrese, P Portincasa… - Microorganisms, 2020 - mdpi.com
The complex polymicrobial composition of human gut microbiota plays a key role in health
and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal …

Host variables confound gut microbiota studies of human disease

I Vujkovic-Cvijin, J Sklar, L Jiang, L Natarajan, R Knight… - Nature, 2020 - nature.com
Low concordance between studies that examine the role of microbiota in human diseases is
a pervasive challenge that limits the capacity to identify causal relationships between host …

Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data

J Chong, P Liu, G Zhou, J Xia - Nature protocols, 2020 - nature.com
MicrobiomeAnalyst is an easy-to-use, web-based platform for comprehensive analysis of
common data outputs generated from current microbiome studies. It enables researchers …

Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health

A Mukherjee, C Lordan, RP Ross, PD Cotter - Gut microbes, 2020 - Taylor & Francis
Over the last two decades our understanding of the gut microbiota and its contribution to
health and disease has been transformed. Among a new 'generation'of potentially beneficial …

The microbiome and inflammatory bowel disease

KL Glassner, BP Abraham, EMM Quigley - Journal of Allergy and Clinical …, 2020 - Elsevier
Inflammatory bowel disease (IBD) is a chronic immune-mediated disease affecting the
gastrointestinal tract. IBD consists of 2 subtypes: ulcerative colitis and Crohn disease. IBD is …

Host–microbiota interactions in inflammatory bowel disease

R Caruso, BC Lo, G Núñez - Nature Reviews Immunology, 2020 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

VIBRANT: automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences

K Kieft, Z Zhou, K Anantharaman - Microbiome, 2020 - Springer
Background Viruses are central to microbial community structure in all environments. The
ability to generate large metagenomic assemblies of mixed microbial and viral sequences …

The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis

S Kitamoto, H Nagao-Kitamoto, Y Jiao, MG Gillilland… - Cell, 2020 - cell.com
The precise mechanism by which oral infection contributes to the pathogenesis of extra-oral
diseases remains unclear. Here, we report that periodontal inflammation exacerbates gut …

Understanding the impact of antibiotic perturbation on the human microbiome

DJ Schwartz, AE Langdon, G Dantas - Genome medicine, 2020 - Springer
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses
that performs essential functions for immune development, pathogen colonization …