Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …

Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its
propensity for early local and distant spread, affected patients possess extremely poor …

Combination chemotherapy, administrating two chemotherapeutic agents concurrently,
comes into prominence, as the heterogeneity or the level of the disease necessitates a …

Regulated cell death (RCD) guarantees to preserve organismal homeostasis. Apoptosis and
autophagy are two major arms of RCD, while endoplasmic reticulum (ER) as a crucial …

Curcumin is a naturally occurring nutraceutical compound with a number of therapeutic and
biological activities such as antioxidant, antiinflammatory, antidiabetic, antitumor, and …

Immune response, proliferation, migration and angiogenesis are juts a few of cellular events
that are regulated by transforming growth factor-β (TGF-β) in cells. A number of studies have …

Cancer is one of the most complicated diseases in present-day medical science. Yearly,
several studies suggest various strategies for preventing carcinogenesis. Furthermore …

Background Curcumin is a natural phytochemical polyphenol with significant anti-cancer
effects and negligible side effects. In this study, the therapeutic capacity of nanomicellar …

Mitochondria are intracellular organelles with two distinct membranes, known as an outer
mitochondrial membrane and inner cell membrane. Originally, mitochondria have been …

Cancer has become a significant public health problem with high disease burden and
mortality. At present, radiotherapy and chemotherapy are the main means of treating cancer …