Duchenne muscular dystrophy (DMD) is an X-linked recessive disease resulting in the loss
of dystrophin, a key cytoskeletal protein in the dystrophin-glycoprotein complex. Dystrophin …

Sarcopenia has a significant negative impact on healthspan in the elderly and effective
pharmacologic interventions remain elusive. We have previously demonstrated that …

Loss of dystrophin leads to Duchenne muscular dystrophy (DMD). A pathogenic feature of
DMD is the significant elevation of cytosolic calcium. Supraphysiological calcium triggers …

Background Dystrophin deficiency sensitizes skeletal muscle of mice to eccentric contraction
(ECC)-induced strength loss. ECC protocols distinguish dystrophin-deficient from healthy …

We describe a technique for simultaneous quantification of the contractile forces and
cytosolic calcium dynamics of muscle fibers embedded in three-dimensional biopolymer …

Duchenne Muscular Dystrophy (DMD) is a severe muscle wasting disorder caused by a
mutation in the dystrophin gene. The dystrophin-deficient mdx mouse is the most common …