Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Chronic pain is a serious public health problem with a strong affective-motivational
component that makes it difficult to treat. Most patients with chronic pain suffer from severe …

Paclitaxel-induced neuropathic pain (PINP) is a dose-limiting side effect and is refractory to
widely used analgesic drugs. Previous studies have demonstrated a protective role of …

Spinal cord injury (SCI) causes neurodegeneration, impairs locomotor function, and impacts
the quality of life particularly in those individuals in whom neuropathic pain develops …

Neuropathic pain, as the most common chronic and intractable neurological disorder,
seriously endangers the health and even life of patients. Due to the unclear mechanism …

Signaling mediated by soluble epoxide hydrolase (sEH) has been reported to play an
important role in pain processing. Previous studies revealed that sEH activity is inhibited by …