Deregulation of E3 ubiquitin ligases is intimately implicated in breast cancer pathogenesis
and progression, but the underlying mechanisms still remain elusive. Here we report that …

Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and
metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha …

Colon cancer is the third most commonly diagnosed cancer in the United States. Recent
reports have shown that the location of the primary tumor is of clinical importance. Patients …

Exosomal heat shock proteins (Hsps) are involved in intercellular communication both in
physiological and pathological conditions. They play a role in key processes of …

Cancer is a multifactorial condition that originates from genomic alterations in the cells,
which confer them the ability to evade various cellular regulations and proliferate …

Introduction Tumor cells have higher metabolic rates compared to normal cells. Biochemical
reactions require properly folded proteins to perform pathway specific functions. Nascent …