Androgens are effective bronchodilators with anti-inflammatory properties: A potential alternative for asthma therapy

LM Montaño, E Flores-Soto, B Sommer… - Steroids, 2020 - Elsevier
Abstract Changes in plasma androgen levels in asthmatic men may be linked to asthma
severity, seemingly acting through nongenomic and genomic effects. Nongenomic effects …

[HTML][HTML] Sex‐specific differences in chronic thromboembolic pulmonary hypertension. Results from the European CTEPH registry

S Barco, FA Klok, SV Konstantinides… - Journal of Thrombosis …, 2020 - Elsevier
Background Women are more susceptible than men to several forms of pulmonary
hypertension, but have better survival. Sparse data are available on chronic thromboembolic …

Sex-specific stress response and HMGB1 release in pulmonary endothelial cells

M Zemskova, S Kurdyukov, J James, N McClain… - PLoS …, 2020 - journals.plos.org
Women are known to be associated with a higher susceptibility to pulmonary arterial
hypertension (PAH). In contrast, male PAH patients have a worse survival prognosis. In this …

Targeted drugs for treatment of pulmonary arterial hypertension: past, present, and future perspectives

W Zheng, Z Wang, X Jiang, Q Zhao… - Journal of Medicinal …, 2020 - ACS Publications
Pulmonary arterial hypertension (PAH) is a devastating disease that can lead to right
ventricular failure and premature death. Although approved drugs have been shown to be …

Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension

P Türck, S Fraga, I Salvador, C Campos-Carraro… - Nutrition, 2020 - Elsevier
Objectives Pulmonary arterial hypertension (PAH) is a condition characterized by an
increased resistance of pulmonary vasculature, culminating in an increase in pulmonary …

Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension

RS Virgincar, JC Nouls, Z Wang, S Degan, Y Qi… - Scientific Reports, 2020 - nature.com
Hyperpolarized 129Xe magnetic resonance imaging (MRI) is capable of regional mapping
of pulmonary gas-exchange and has found application in a wide range of pulmonary …

Estrogen administration reduces the risk of pulmonary arterial hypertension by modulating the miR-133a signaling pathways in rats

S Zhou, K Zhu, Y Du, H Jiang, M Li, P Wu, A Xu, X Ding… - Gene Therapy, 2020 - nature.com
We aimed to investigate how estrogen (ES) is implicated in the pathogenesis of pulmonary
arterial hypertension (PAH) potentially by reducing the extent of vascular remodeling in …

Spontaneous pulmonary hypertension associated with systemic sclerosis in P‐selectin glycoprotein ligand 1–deficient mice

R González‐Tajuelo… - Arthritis & …, 2020 - Wiley Online Library
Objective Pulmonary arterial hypertension (PAH), one of the major complications of systemic
sclerosis (SSc), is a rare disease with unknown etiopathogenesis and noncurative …

Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary …

R Hashimoto, GM Lanier, V Dhagia… - … of Physiology-Lung …, 2020 - journals.physiology.org
Pulmonary hypertension (PH) is a multicellular and progressive disease with a high mortality
rate. Among many cell types, hematopoietic stem cells (HSCs) are incriminated in the …

NFU1, Iron-sulfur biogenesis, and pulmonary arterial hypertension: a (metabolic) shift in our thinking

MK Culley, D Perk, SY Chan - American Journal of Respiratory Cell …, 2020 - atsjournals.org
Pulmonary hypertension (PH) is a progressive, enigmatic disease of the lung vasculature
that is clinically defined by elevated mean pulmonary arterial pressure and pulmonary …