100 years of suramin
N Wiedemar, DA Hauser, P Mäser - Antimicrobial agents and …, 2020 - Am Soc Microbiol
Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …
Autism spectrum disorder as a brain-gut-microbiome axis disorder
V Saurman, KG Margolis, RA Luna - Digestive diseases and sciences, 2020 - Springer
While there are numerous medical comorbidities associated with ASD, gastrointestinal (GI)
issues have a significant impact on quality of life for these individuals. Recent findings …
issues have a significant impact on quality of life for these individuals. Recent findings …
[HTML][HTML] Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model
MD Bauman, J Van de Water - Neurobiology of disease, 2020 - Elsevier
The prenatal environment, and in particular, the maternal-fetal immune environment, has
emerged as a targeted area of research for central nervous system (CNS) diseases with …
emerged as a targeted area of research for central nervous system (CNS) diseases with …
Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism
MM Hirsch, I Deckmann, J Santos-Terra, GZ Staevie… - …, 2020 - Elsevier
Autism spectrum disorder (ASD) is characterized by deficits in communication and social
interaction, restricted interests, and stereotyped behavior. Environmental factors, such as …
interaction, restricted interests, and stereotyped behavior. Environmental factors, such as …
Untargeted metabolomics screen of mid‐pregnancy maternal serum and autism in offspring
Discovering pathophysiologic networks in a blood‐based approach may help to generate
valuable tools for early treatment or preventive measures in autism. To date targeted or …
valuable tools for early treatment or preventive measures in autism. To date targeted or …
Neuropsychiatric consequences of childhood group A streptococcal infection: A systematic review of preclinical models
In recent years, clinical studies have shown strong epidemiological evidence of an
increased risk of developing neuropsychiatric disorders after childhood exposure to …
increased risk of developing neuropsychiatric disorders after childhood exposure to …
Old polyanionic drug suramin suppresses detrimental cytotoxicity of the host defense peptide LL-37
M Quemé-Peña, M Ricci, T Juhász… - ACS Pharmacology & …, 2020 - ACS Publications
The host defense peptide LL-37 is the only human cathelicidin, characterized by pleiotropic
activity ranging from immunological to anti-neoplastic functions. However, its overexpression …
activity ranging from immunological to anti-neoplastic functions. However, its overexpression …
[HTML][HTML] The key role of purine metabolism in the folate-dependent phenotype of autism spectrum disorders: an in silico analysis
J Geryk, D Krsička, M Vlčková, M Havlovicová… - Metabolites, 2020 - mdpi.com
Folate deficiency in the critical developmental period has been repeatedly associated with
an increased risk of Autism spectrum disorders (ASD), but the key pathophysiological …
an increased risk of Autism spectrum disorders (ASD), but the key pathophysiological …
Metabolic and Behavioral Features of Acute Hyperpurinergia and the Connection to Autism Spectrum Disorder
Z Zolkipli-Cunningham, JC Naviaux, T Nakayama… - 2020 - researchsquare.com
Background. Since 2012, studies in mice, rats, and humans have suggested that
abnormalities in purinergic signaling may be a final common pathway for many genetic and …
abnormalities in purinergic signaling may be a final common pathway for many genetic and …