UTIs are amongst the most frequent bacterial infections. However, the clinical phenotypes of
UTI are heterogeneous and range from rather benign, uncomplicated infections to …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a
growing concern due to limited treatment options. Knowledge of the common uropathogens …

Background The literature on the epidemiology, mortality and treatment of pandrug-resistant
(PDR) Gram-negative bacteria (GNB) is scarce, scattered and controversial. Objectives To …

The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

Extended spectrum β-lactamase (ESBL)-producing bacteria are prevalent worldwide and
correlated with hospital infections, but they have been evolving as an increasing cause of …

Fosfomycin is being increasingly prescribed for multidrug-resistant bacterial infections. In
patients with systemic involvement, intravenous fosfomycin is usually administered as a …

Abstract Purpose of Review Gram-negative resistance is a growing concern globally.
Enterobacterales, formerly Enterobacteriaceae, have developed resistance mechanisms to …

There has been growing interest in fosfomycin for the treatment of bacterial prostatitis due to
evidence suggesting that it achieves adequate prostatic concentrations for antimicrobial …

Antimicrobial resistance is an important global issue that impacts the efficacy of established
antimicrobial therapy. This is true globally and within the Arab countries of the Middle East …