Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …

Lung cancer is one of the most malignant cancers around the world, with high morbidity and
mortality. Metastasis is the leading cause of lung cancer deaths and treatment failure …

Background Anti-angiogenic therapy represents a promising strategy for non-small-cell lung
cancer (NSCLC) but its application in lung squamous cell carcinoma (SQC) is limited due to …

Temozolomide (TMZ) resistance is a major cause of recurrence and poor prognosis in
glioblastoma (GBM). Recently, increasing evidences suggested that long noncoding RNAs …

Cancer drug resistance and epithelial-mesenchymal transition (EMT), a critical process of
cancer invasion and metastasis, have recently been associated with the existence of cancer …

Bone metastasis is associated with cancer‐related death in patients with prostate cancer
(PCa). Long noncoding RNAs (lncRNAs) play critical roles in tumor progression of PCa …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. A common and
disabling disease of the elderly, the standard dopamine replacement therapies do not arrest …

Vascular calcification (VC) is an important complication among patients of advanced age,
those with chronic kidney disease, and those with diabetes mellitus. The pathophysiology of …

Malignant pleural mesothelioma (MPM) is a tumor with high chemoresistance and poor
prognosis. MPM‐initiating cells (ICs) are known to be drug resistant, but it is unknown if and …

In osteoarthritis (OA), the synthesis and decomposition of the extracellular matrix (ECM) are
imbalanced. High expression levels of Wnt1-inducible signaling pathway protein 1 (WISP1) …