COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

TJ Guzik, SA Mohiddin, A Dimarco, V Patel… - Cardiovascular …, 2020 - academic.oup.com
The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents
the greatest medical challenge in decades. We provide a comprehensive review of the …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …

Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19: European Society of …

R Kreutz, EAEH Algharably, M Azizi… - Cardiovascular …, 2020 - academic.oup.com
Systemic arterial hypertension (referred to as hypertension herein) is a major risk factor of
mortality worldwide, and its importance is further emphasized in the context of the novel …

COVID-19 patients with hypertension have more severe disease: a multicenter retrospective observational study

S Huang, J Wang, F Liu, J Liu, G Cao, C Yang… - Hypertension …, 2020 - nature.com
This study aims to explore the effect of hypertension on disease progression and prognosis
in patients with coronavirus disease 2019 (COVID-19). A total of 310 patients diagnosed …

Periodontitis is associated with hypertension: a systematic review and meta-analysis

E Munoz Aguilera, J Suvan, J Buti… - Cardiovascular …, 2020 - academic.oup.com
Recent evidence suggests a link between periodontitis (PD) and hypertension, but the
nature of this association remains unclear. The overall aim of this review was to critically …

Role of monocytes/macrophages in Covid-19 pathogenesis: implications for therapy

J Gómez-Rial, I Rivero-Calle, A Salas… - Infection and Drug …, 2020 - Taylor & Francis
cov-Abstract Emerging studies from SARS-CoV-2-infected patients indicate a preponderant
role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to …

White blood cells and blood pressure: a Mendelian randomization study

M Siedlinski, E Jozefczuk, X Xu, A Teumer… - Circulation, 2020 - Am Heart Assoc
Background: High blood pressure (BP) is a risk factor for cardiovascular morbidity and
mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic …

Effects of hypertension, diabetes and coronary heart disease on COVID-19 diseases severity: a systematic review and meta-analysis

Y Chen, X Gong, L Wang, J Guo - MedRxiv, 2020 - medrxiv.org
Background COVID-19 patients with chronic diseases such as hypertension, diabetes and
coronary heart diseases is more likely to worsen, but with mixed results for COVID-19 …

Association of hypertension with all-cause mortality among hospitalized patients with COVID-19

E Rodilla, A Saura, I Jimenez, A Mendizabal… - Journal of clinical …, 2020 - mdpi.com
It is unclear to which extent the higher mortality associated with hypertension in the
coronavirus disease (COVID-19) is due to its increased prevalence among older patients or …

[HTML][HTML] Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology

E Józefczuk, TJ Guzik, M Siedlinski - Pharmacological research, 2020 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …