Investigating the role of glutamate in obsessive-compulsive disorder: current perspectives

S Karthik, LP Sharma… - … disease and treatment, 2020 - Taylor & Francis
Glutamate is a ubiquitous excitatory neurotransmitter, which is involved in normal
physiology, a variety of central nervous system (CNS) functions, including excitotoxicity and …

Diagnostic biomarkers for obsessive-compulsive disorder: A reasonable quest or ignis fatuus?

MA Fullana, A Abramovitch, E Via, C López-Sola… - Neuroscience & …, 2020 - Elsevier
Obsessive-compulsive disorder (OCD) has been associated with a wide range of biological
and neurocognitive findings, which could assist in the search for biomarkers. We conducted …

Examination of the shared genetic basis of anorexia nervosa and obsessive–compulsive disorder

Z Yilmaz, M Halvorsen, J Bryois, D Yu… - Molecular …, 2020 - nature.com
Anorexia nervosa (AN) and obsessive–compulsive disorder (OCD) are often comorbid and
likely to share genetic risk factors. Hence, we examine their shared genetic background …

Bayesian weighted Mendelian randomization for causal inference based on summary statistics

J Zhao, J Ming, X Hu, G Chen, J Liu, C Yang - Bioinformatics, 2020 - academic.oup.com
Abstract Motivation The results from Genome-Wide Association Studies (GWAS) on
thousands of phenotypes provide an unprecedented opportunity to infer the causal effect of …

De novo damaging DNA coding mutations are associated with obsessive-compulsive disorder and overlap with Tourette's disorder and autism

C Cappi, ME Oliphant, Z Péter, G Zai, MC do Rosário… - Biological …, 2020 - Elsevier
Background Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric
disorder with a genetic risk component, yet identification of high-confidence risk genes has …

Oxytocin receptor gene DNA methylation: a biomarker of treatment response in obsessive-compulsive disorder?

MA Schiele, C Thiel, L Kollert, L Fürst… - Psychotherapy and …, 2020 - karger.com
Introduction: Obsessive-compulsive disorder (OCD) is associated with high chronicity and
treatment resistance, indicating the need for early therapy response markers enabling fast …

Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation

SJ Goodman, CL Burton, DT Butcher, MT Siu… - Journal of …, 2020 - Springer
Background A growing body of research has demonstrated associations between specific
neurodevelopmental disorders and variation in DNA methylation (DNAm), implicating this …

Neurocognitive risk markers in pediatric obsessive–compulsive disorder

J Negreiros, L Belschner, JR Best, S Lin… - Journal of Child …, 2020 - Wiley Online Library
Background Obsessive–compulsive disorder (OCD) has complex genetic underpinnings,
particularly in its early‐onset form, which places siblings at a 10‐fold increased risk of …

Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling

J Bralten, J Widomska, WD Witte, D Yu… - Translational …, 2020 - nature.com
Obsessive-compulsive symptoms (OCS) in the population have been linked to obsessive-
compulsive disorder (OCD) in genetic and epidemiological studies. Insulin signaling has …

The polygenic risk for obsessive‐compulsive disorder is associated with the personality trait harm avoidance

K Bey, L Weinhold, R Grützmann… - Acta Psychiatrica …, 2020 - Wiley Online Library
Objective Obsessive‐compulsive disorder (OCD) is a complex psychiatric disorder with a
substantial genetic contribution. While the specific variants underlying OCD's heritability are …