Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

Post-translational modifications controlling a large number of biological functions are key
aspects of protein diversity. They have an important role controlling cellular processes and …

Phosphorylation is a common process for regulating protein functions. Studies have
confirmed that many human diseases are associated with the abnormal phosphorylation of …

Lysine succinylation (Ksucc), defined as a transfer of a succinyl group to a lysine residue of
a protein, is a newly identified protein post-translational modification 1–3. This chemical …

Among all the PTMs, the protein phosphorylation is pivotal for various pathological and
physiological processes. About 30 percent of eukaryotic proteins undergo the …

In mammalian cells, tyrosine phosphorylation is one of the main mechanisms responsible for
regulating signal transduction pathways and key cellular functions. Moreover, recent studies …

The global burden of Alzheimer's disease (AD) is growing. Valiant efforts to develop clinical
candidates for treatment have continuously met with failure. Currently available palliative …

The presentation of peptides on class I human leukocyte antigen (HLA-I) molecules plays a
central role in immune recognition of infected or malignant cells. In cancer, non-self HLA-I …

More than 300 different protein post‐translational modifications are currently known, but only
a few have been extensively investigated because modified proteoforms are commonly …

This study sought to examine the functional significance of mitochondrial protein acetylation
using a double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl …