Respiratory viruses remain a significant cause of morbidity and mortality in the human
population, underscoring the importance of ongoing basic research into virus–host …

The concept that increasing airway hydration leads to improvements in mucus clearance
and lung function in cystic fibrosis has been clinically validated with osmotic agents such as …

Rationale: Enhancing non–CFTR (cystic fibrosis transmembrane conductance regulator)-
mediated anion secretion is an attractive therapeutic approach for the treatment of cystic …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease
characterized by patchy scarring of the distal lung with limited therapeutic options and poor …

In vitro cultures of primary human airway epithelial cells (hAECs) grown at air–liquid
interface have become a valuable tool to study airway biology under normal and pathologic …

Exposure of lung airways to detrimental suspended aerosols in the environment increases
the vulnerability of the respiratory and cardiovascular systems. In addition, recent …

Due to pioneering in vitro investigations on gene modification, gene engineering platforms
have incredibly improved to a safer and more powerful tool for the treatment of multiple …

In vitro models of the human lung play an essential role in evaluating the toxicity of inhaled
compounds and understanding the development of respiratory diseases. Three-dimensional …

E-cigarettes are noncombustible, electronic nicotine-delivery devices that aerosolize an e-
liquid, ie, nicotine, in a propylene glycol-vegetable glycerin vehicle that also contains flavors …

Early-life viral infections are responsible for pulmonary exacerbations that can contribute to
disease progression in young children with cystic fibrosis (CF). The most common …