[HTML][HTML] Amplifying immunogenicity of prospective Covid-19 vaccines by glycoengineering the coronavirus glycan-shield to present α-gal epitopes

U Galili - Vaccine, 2020 - Elsevier
The many carbohydrate chains on Covid-19 coronavirus SARS-CoV-2 and its S-protein form
a glycan-shield that masks antigenic peptides and decreases uptake of inactivated virus or S …

Self-adjuvanting cancer vaccines from conjugation-ready lipid A analogues and synthetic long peptides

NRM Reintjens, E Tondini, AR de Jong… - Journal of medicinal …, 2020 - ACS Publications
Self-adjuvanting vaccines, wherein an antigenic peptide is covalently bound to an
immunostimulating agent, have been shown to be promising tools for immunotherapy …

Integrin α4β7 in HIV-1 infection: A critical review

Q Liu, P Lusso - Journal of Leucocyte Biology, 2020 - academic.oup.com
Over the past decade, a series of observations linking α4β7, the principal gut‐homing
integrin, with various aspects of HIV‐1 infection have generated considerable interest in the …

[HTML][HTML] Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection

R Desikan, R Raja, NM Dixit - PLoS computational biology, 2020 - journals.plos.org
Antiretroviral therapy (ART) for HIV-1 infection is life-long. Stopping therapy typically leads to
the reignition of infection and progressive disease. In a major breakthrough, recent studies …

[HTML][HTML] Host synthesized carbohydrate antigens on viral glycoproteins as “Achilles' heel” of viruses contributing to anti-viral immune protection

U Galili - International Journal of Molecular Sciences, 2020 - mdpi.com
The glycans on enveloped viruses are synthesized by host-cell machinery. Some of these
glycans on zoonotic viruses of mammalian reservoirs are recognized by human natural …

[HTML][HTML] B cell targeting by molecular adjuvants for enhanced immunogenicity

T Sicard, A Kassardjian, JP Julien - Expert Review of Vaccines, 2020 - Taylor & Francis
Introduction Adjuvants are critical components of vaccines to improve the quality and
durability of immune responses. Molecular adjuvants are a specific subclass of adjuvants …

[HTML][HTML] A new humanized mouse model mimics humans in lacking α-Gal epitopes and secreting anti-gal antibodies

FM Saleh, PK Chandra, D Lin, JE Robinson… - The Journal of …, 2020 - journals.aai.org
Mice have been used as accepted tools for investigating complex human diseases and new
drug therapies because of their shared genetics and anatomical characteristics with …

[PDF][PDF] Roles of Human Respiratory Syncytial Virus Proteins in Immune Responses

F Wang, L Zhao - Archives of Clinical and Biomedical Research, 2020 - fortuneonline.org
Human respiratory syncytial virus (hRSV) has evaded active vaccination or effective antiviral
therapy for decades and continues to be the leading cause of morbidity and hospitalization …

Mécanismes de l'immunothérapie épicutanée des allergies alimentaires

L Laoubi - 2020 - theses.hal.science
L'allergie alimentaire est un problème majeur de santé publique qui affecte grandement la
qualité de vie des patients, principalement des enfants, et peut causer des symptômes …