[HTML][HTML] What are the current approaches to optimising antimicrobial dosing in the intensive care unit?

MG Chai, MO Cotta, MH Abdul-Aziz, JA Roberts - Pharmaceutics, 2020 - mdpi.com
Antimicrobial dosing in the intensive care unit (ICU) can be problematic due to various
challenges including unique physiological changes observed in critically ill patients and the …

Meropenem–nacubactam activity against AmpC-overproducing and KPC-expressing Pseudomonas aeruginosa in a neutropenic murine lung infection model

TE Asempa, A Motos, K Abdelraouf, C Bissantz… - International journal of …, 2020 - Elsevier
Nacubactam is a novel non-β-lactam diazabicyclooctane β-lactamase inhibitor under
development for the treatment of serious Gram-negative infections. This study assessed the …

External evaluation of population pharmacokinetic models for continuous administration of meropenem in critically ill adult patients

YL Wang, R Guilhaumou, O Blin, L Velly… - European Journal of …, 2020 - Springer
Abstract Purpose Beta-lactams (BL), the most commonly prescribed class of antibiotics, are
recommended as the first-line therapy for multiple indications in infectious disease …

[PDF][PDF] Corrigendum to “Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: A prospective observational study …

SAM Dhaese, ADJ Thooft, A Farkas, J Lipman… - Journal of Critical …, 2020 - academia.edu
The authors regret that in the manuscript under section 2.3 Definition of target attainment the
following is written:“Based on this data, an unbound TZP concentration of 160 mg/L and an …