Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for
the core motor deficits of Parkinson's disease (PD). These neurons are autonomous …

Background Neurotrophic factors are endogenous proteins promoting the survival of
different neural cells. Therefore, they elicited great interest as a possible treatment for …

Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of striatal
dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the …

α-Synuclein is expressed at high levels at presynaptic terminals, but defining its role in the
regulation of neurotransmission under physiologically relevant conditions has proven …

Calcium signaling is critical to neuronal function and regulates highly diverse processes
such as gene transcription, energy production, protein handling, and synaptic structure and …

Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by the
progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and …

Parkinson's disease (PD) is the second most common neurodegenerative disease, disabling
millions worldwide. Despite the imperative PD poses, at present, there is no cure or means …

Mitochondria are very dynamic organelle which plays a multifactorial role for a broad range
of physiological processes inside the cell to maintain neural circuit integrity. They are …

Mitochondrial dysfunction is critically involved in Parkinson's disease, characterized by loss
of dopaminergic neurons (DaNs) in the substantia nigra (SNc), whereas DaNs in the …

Manganese exposure produces Parkinson's-like neurologic symptoms, suggesting a
selective dysregulation of dopamine transmission. It is unknown, however, how manganese …