[HTML][HTML] Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer
The role of dysregulation of mRNA alternative splicing (AS) in the development and
progression of solid tumors remains to be defined. Here we describe the first comprehensive …
progression of solid tumors remains to be defined. Here we describe the first comprehensive …
[HTML][HTML] Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer
JM Jiménez-Vacas, V Herrero-Aguayo… - …, 2020 - thelancet.com
Background Dysregulation of splicing variants (SVs) expression has recently emerged as a
novel cancer hallmark. Although the generation of aberrant SVs (eg AR-v7/sst5TMD4/etc.) is …
novel cancer hallmark. Although the generation of aberrant SVs (eg AR-v7/sst5TMD4/etc.) is …
[HTML][HTML] Robustness during aging—molecular biological and physiological aspects
Understanding the process of aging is still an important challenge to enable healthy aging
and to prevent age-related diseases. Most studies in age research investigate the decline in …
and to prevent age-related diseases. Most studies in age research investigate the decline in …
rMAPS2: an update of the RNA map analysis and plotting server for alternative splicing regulation
JY Hwang, S Jung, TL Kook, EC Rouchka… - Nucleic Acids …, 2020 - academic.oup.com
Abstract The rMAPS2 (R NA M ap A nalysis and P lotting S erver 2) web server, freely
available at http://rmaps. cecsresearch. org/, has provided the high-throughput sequencing …
available at http://rmaps. cecsresearch. org/, has provided the high-throughput sequencing …
[HTML][HTML] Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer
M Freytag, M Kluth, E Bady, C Hube-Magg… - Bmc Cancer, 2020 - Springer
Background Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2) regulate
alternative splicing events of various pre-mRNAs. Some of these targets play a role in …
alternative splicing events of various pre-mRNAs. Some of these targets play a role in …
A novel splice variant of LOXL2 promotes progression of human papillomavirus–negative head and neck squamous cell carcinoma
C Liu, T Guo, A Sakai, S Ren, T Fukusumi, M Ando… - Cancer, 2020 - Wiley Online Library
Background Head and neck squamous cell carcinoma (HNSCC) is one of the most
frequently diagnosed cancers worldwide. LOXL2 demonstrates alternative splicing events in …
frequently diagnosed cancers worldwide. LOXL2 demonstrates alternative splicing events in …
[HTML][HTML] Epithelial splicing regulatory protein (ESPR1) expression in an unfavorable prognostic factor in prostate cancer patients
Background To evaluate the role of epithelial splicing regulatory protein 1 (ESRP1)
expression in survival prognoses and disease progression for prostate cancer (PC) using …
expression in survival prognoses and disease progression for prostate cancer (PC) using …
[PDF][PDF] 上皮剪接调节蛋白1 的研究进展
贾静， 马百涛， 朱盛兰， 王少帅， 冯玲 - 现代生物医学进展, 2020 - biomed.cnjournals.com
上皮剪接调节蛋白1 (Epithelial splicing regulatory protein 1, ESRP1) 是近年来发现的一种上皮
细胞特异性剪接因子, 主要通过选择性剪接在转录后水平调节基因的表达, 继而影响细胞的功能 …
细胞特异性剪接因子, 主要通过选择性剪接在转录后水平调节基因的表达, 继而影响细胞的功能 …
Splicing and Alternative Splicing and the Impact of Mechanics
CT Mierke, CT Mierke - Cellular Mechanics and Biophysics: Structure and …, 2020 - Springer
Abstract Systems-wide approaches have gained new insights into mRNA splicing. Improved
cryo-EM techniques have elucidated the structure of splice components. Recent findings on …
cryo-EM techniques have elucidated the structure of splice components. Recent findings on …
Identification of Prognostic Alternative Splicing Signature in Triple-negative breast cancer
S Zhou, S Guan, X Lv, R Ma, Y Zhang, Y Yan, J Wang… - 2020 - researchsquare.com
Background: Alternative splicing (AS) is a pervasive and vital mechanism involved in the
progression of various cancer. Studies confirm the importance of prognostic value of AS …
progression of various cancer. Studies confirm the importance of prognostic value of AS …