Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …

Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Microglia maintain brain homeostasis by removing neuron-derived components such as
myelin and cell debris. The evidence linking microglia to neurodegenerative diseases is …

Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …

The accumulation of abnormal protein aggregates represents a universal hallmark of
neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate …

Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease
(PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase …

Several lines of evidence from neuropathological studies, human genetics, in vitro
aggregation studies and cellular and animal models support the hypothesis that aSyn plays …

Background Parkinson's disease (PD) is the most common movement disorder among
adults, affecting 2% of the world population older than 65 years of age. No diagnostic …