Recent advancements of coumarin-based anticancer agents: An up-to-date review

T Al-Warhi, A Sabt, EB Elkaeed, WM Eldehna - Bioorganic Chemistry, 2020 - Elsevier
Heading the list of the critical health-related issues worldwide, cancer continues to be a one
of the most serious life-threatening diseases. The rate of cancer-related mortality is at …

Antibacterial activities with the structure-activity relationship of coumarin derivatives

HL Qin, ZW Zhang, L Ravindar, KP Rakesh - European journal of medicinal …, 2020 - Elsevier
The development of drug-resistant bacteria, as well as multidrug-resistant pathogens related
to substantial mortality, is an important global health threat. The wide range of biological …

Synthesis of biologically active molecules through multicomponent reactions

D Insuasty, J Castillo, D Becerra, H Rojas, R Abonia - Molecules, 2020 - mdpi.com
Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

Pyrazoline hybrids as promising anticancer agents: An up-to-date overview

D Matiadis, M Sagnou - International Journal of Molecular Sciences, 2020 - mdpi.com
Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have
attracted significant attention from organic and medicinal chemists due to their potent …

Coumarin derivatives with anticancer activities: An update

XF Song, J Fan, L Liu, XF Liu, F Gao - Archiv der Pharmazie, 2020 - Wiley Online Library
Cancer can invade or spread to almost all parts of the body. The increasing morbidity and
high mortality of cancer create a great demand for the development of novel anticancer …

Artemisinin-derived hybrids and their anticancer activity

F Gao, Z Sun, F Kong, J Xiao - European journal of medicinal chemistry, 2020 - Elsevier
The emergence of drug-resistance and the low specificity of anticancer agents are the major
challenges in the treatment of cancer and can result in many side effects, creating an urgent …

Recent advances in the synthesis of coumarin derivatives from different starting materials

M Lončarić, D Gašo-Sokač, S Jokić, M Molnar - Biomolecules, 2020 - mdpi.com
The study of coumarin dates back to 1820 when coumarin was first extracted from tonka
bean by Vogel. Compounds containing coumarin backbone are a very important group of …

[HTML][HTML] Identification and quantification of phenolic acid compounds of twenty-six mushrooms by HPLC–DAD

F Çayan, E Deveci, G Tel-Çayan, ME Duru - Journal of Food Measurement …, 2020 - Springer
Phenolic acids are found in different foods in the human diet, for example mushrooms.
Determination of phenolic acids is important because of their relationship to their role in …

Recurrent π–π stacking motifs in three new 4, 5-dihydropyrazolyl–thiazole–coumarin hybrids: X-ray characterization, Hirshfeld surface analysis and DFT calculations

M Madni, MN Ahmed, M Hafeez, M Ashfaq… - New Journal of …, 2020 - pubs.rsc.org
The synthesis and X-ray characterization of three new 4, 5-dihydropyrazolylthiazole–
coumarin hybrids (1–3) are reported herein, namely 3-(2-(3, 5-bis (4-chlorophenyl)-4, 5 …

Discovery of novel coumarin analogs against the α-glucosidase protein target of Diabetes mellitus: Pharmacophore-based QSAR, docking, and molecular dynamics …

AK Maurya, V Mulpuru, N Mishra - ACS omega, 2020 - ACS Publications
Diabetes mellitus (DM) is a chronic metabolic disease, the third killer of mankind. The finding
of potent drugs against diabetes remains challenging. In the present study, coumarin …