The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

The lifestyle adopted by most people in Western societies has an important impact on the
propensity to metabolic disorders (eg, diabetes, cancer, cardiovascular disease …

Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse
species. However, only few circRNAs have been functionally characterized, and their role …

A substantial body of research now implicates the circadian clock in the regulation of an
array of diverse biological processes including glial function, metabolism, peripheral …

Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health
and increasing lifespan. CR exerts its effects through multiple molecular pathways that …

While the growth hormone/insulin-like growth factor-1 (GH/IGF-1) pathway plays essential
roles in growth and development, diminished signaling via this pathway in model organisms …

Genetic and environmental factors are key drivers regulating organismal lifespan but how
these impact healthspan is less well understood. Techniques capturing biomechanical …

The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control,
immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC …

Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules
vital for proper cellular function. Although this process is fundamentally haphazard and …