Chronic liver disease and primary liver cancer are a massive global problem, with a future
increase in incidences predicted. The most prevalent form of primary liver cancer …

Metabolism is a fundamental cellular process that can become harmful for cells by leading to
DNA damage, for instance by an increase in oxidative stress or through the generation of …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

The evolutionary history of horseshoe crabs, spanning approximately 500 million years, is
characterized by remarkable morphological stasis and a low species diversity with only four …

Although lifespan in mammals varies over 100-fold, the precise evolutionary mechanisms
underlying variation in longevity remain unknown. Species-specific genetic changes have …

Conceptually and mechanistically, the evolution of multicellularity required the integration of
single cells into new functionally, reproductively and evolutionary stable multicellular …

Cancer is caused by genetic alterations that affect cellular fitness, and multicellular
organisms have evolved mechanisms to suppress cancer such as cell cycle checkpoints …

Simple Summary TP53, the most frequently mutated gene in human cancers, has a key role
in the maintenance of the genetic stability and, thus, in preventing tumor development. The …

Cancer has deep evolutionary roots and is an important source of selective pressure in
organismal evolution. Yet, we find a great deal of variation in cancer vulnerabilities across …

Immune system has evolved to maintain homeostatic balance between effector and
regulatory immunity, which is critical to both elicit an adequate protective response to fight …