Aims: Reactive oxygen species (ROS) are highly reactive molecules generated in different
subcellular sites or compartments, including endosomes via the NOX2-containing …

Excessive activation of pro‐inflammatory M1 macrophages following acute myocardial
infarction (MI) aggravates adverse cardiac remodelling and heart dysfunction. There are two …

The early in vivo diagnosis of infectious disease foci is largely hindered by invasion and
concealment of pathogens in host cells, making it difficult for conventional probes to detect …

Cobalt-chromium-molybdenum (CoCrMo) alloys are used extensively in orthopaedic
applications. However, they can undergo wear and corrosion in vivo, leading to the release …

Select enzymes assemble in complexes forming catalytic networks that channel metabolic
substrates. This channeling can allow utilization of metabolites in low concentrations and …

Cystic Fibrosis (CF) is an autosomal recessive genetic disorder, caused by mutations in the
CF Transmembrane Conductance Regulator (CFTR) gene, which encodes an ion channel …

The impact of T cell senescence during ageing is well established. However, T cell
senescence is now recognised to play a role in a variety of age-related and metabolic …

COPD is major health problem and is set to become the third leading cause of death
globally by 2030. To date we have no therapies which significantly alter the course of this …

BPE Bovine pituitary extract BSA Bovine serum albumin CCL CC Chemokine Ligand CCR
CC Chemokine Receptor CD Cluster of Differentiation cDNA Complementary …